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Glossary Nestin

protein marker in neural stem cells and hair follicle regeneration

Nestin is a type of protein known as an intermediate filament, which is primarily found in neural stem cells and is used as a marker to identify these cells. It plays a crucial role in the development of the nervous system and is also involved in the regeneration of tissues, including hair follicles, making it significant in studies related to hair growth and alopecia.

Research

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research Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons

419 citations , March 2005 in “Proceedings of the National Academy of Sciences”

This study demonstrated that ND-GFP stem cells from the hair-follicle bulge area can differentiate into various cell types, including neurons, suggesting their potential as a source for therapeutic applications.

research Nestin expression in hair follicle sheath progenitor cells

352 citations , August 2003 in “Proceedings of the National Academy of Sciences”

In this study, nestin-expressing cells in the hair follicle bulge, marked by GFP in transgenic mice, were identified as progenitors of the hair follicle outer-root sheath.

research Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells

212 citations , August 2004 in “Proceedings of the National Academy of Sciences”

This study found that nestin-driven GFP labels blood vessels originating from hair follicles in mice, which could be used to study early events in skin angiogenesis and for antiangiogenesis drug screening.

research From hair to heart: nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells differentiate to beating cardiac muscle cells

64 citations , May 2015 in “Cell Cycle”

This study found that hair follicle stem cells from mice can differentiate into beating cardiac muscle cells, suggesting potential applications for heart regeneration in regenerative medicine.

research Nestin‐positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury

57 citations , November 2011 in “The Journal of Dermatology”

This study found that transplanting human hair follicle pluripotent stem cells can promote the recovery of sciatic nerve function in a mouse model of nerve impingement.

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