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GlossaryIntermediate Filaments

structural proteins in cells providing mechanical support and stability

Intermediate filaments are a type of structural protein found within cells that help maintain their shape and integrity. They are part of the cytoskeleton, which also includes microtubules and actin filaments, and they provide mechanical support to cells, enabling them to withstand stress and strain.

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research The Autoimmune Regulator (AIRE), Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17

24 citations, March 2011 in “The American journal of pathology”

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

research A General Mathematical Model for the In Vitro Assembly Dynamics of Intermediate Filament Proteins

5 citations, February 2022 in “Biophysical journal”

The model shows that filament flexibility and amino acid differences affect how fast intermediate filament proteins assemble.

research Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle

116 citations, April 1986 in “The journal of cell biology/The Journal of cell biology”

Trichohyalin is a protein in hair follicles that helps form hair filaments.

research Structure and Mechanical Properties of Human Trichocyte Keratin Intermediate Filament Protein

51 citations, September 2012 in “Biomacromolecules”

Disulfide bonds make keratin in hair stronger and tougher.

research Disulfide Cross-Linked Network Structure of Intermediate Filament and Matrix in Hair and Wool Cortices

4 citations, January 2015 in “Sen'i Gakkaishi”

Hair and wool strength is affected by the number and type of bonds in their protein structures, with hair having more protein aggregates than wool.

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community Is it possible for Dutasteride to make one mentally slow?

in Chat 22 upvotes 3 months ago

Dutasteride may cause mental fog, vision blurriness, and sleep issues. Users suggest trying topical versions of the drug to mitigate side effects.

community What else can I do to compliment Minoxidil?

in Update 4 upvotes 11 months ago

A user has been using minoxidil for hair loss and has seen positive results, but is seeking additional treatments to enhance its effects. One suggestion given is to use finasteride alongside minoxidil.

community Brothers in baldness any news on pyrilutamide

in Chat 12 upvotes 1 year ago

The conversation is about the potential effectiveness of a hair loss treatment called pyrilutamide. One person has been using it since September and reports positive results.

community My slick bald temples ( for about 7-8 years ) FIN MIN KETO MICRONEEDLING 2 months +

in Progress Pictures 54 upvotes 2 years ago

A user sharing their progress after using Fin, Minoxidil, keto diet, and microneedling for two months to attempt to regrow hair on bald temples. Other users replied with advice and support.

community Anti Fibrosis and Calcification regimen?

in Question 10 upvotes 6 years ago

The user experienced no improvement in hair loss with finasteride and minoxidil but had side effects. They plan to add wounding, scalp massage, vitamin K, and taurine supplements to their regimen and seek feedback on these additions.

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