The Autoimmune Regulator (AIRE), Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17

    February 2011 in “ ˜The œAmerican journal of pathology ”
    Vipul Kumar, Luis Alberto Pedroza, Emily M. Mace, Steven H. Seeholzer, George Cotsarelis, Antônio Condino‐Neto, Aimee Payne, Jordan S. Orange
    TLDR AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.
    The study found that the Autoimmune Regulator (AIRE) protein, defective in APECED patients, was expressed in human epidermal and follicular keratinocytes and associated with the intermediate filament protein cytokeratin 17 (K17). This association, confirmed through various methods including mass spectrometry and co-immunoprecipitation, suggested a potential role for AIRE in maintaining skin and hair follicle integrity. The findings provided insights into the ectodermal abnormalities seen in APECED, although the exact functional significance of AIRE's interaction with K17 remained unclear.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 182 results

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  37 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community Wtf have we been doing for the last 30 years

      in Treatment  538 upvotes 1 week ago
      Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

      community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

      in Progress Pictures  492 upvotes 2 years ago
      A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

      community Clascoterone study going on right now

      in Research/Science  356 upvotes 7 months ago
      A user is participating in a phase 3 trial for Clascoterone, a topical acne medication that may stimulate hair growth, and will share results after 6 months. They will have a section of their hair shaved and marked with a tattoo for the study.

      community Why I deleted my YouTube channel Part I

      in Update  118 upvotes 3 years ago
      A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

    Similar Research

    5 / 1000+ results