Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression, with Alopecia Areata in Males: A Case-Control Study

    October 2019 in “ Immunological investigations ”
    Eman A. Toraih, Hatem Mohamed Ameen, Mohammad Hussein, Ahmed A. Youssef Elabd, Abeer Mohamed, Abdelhady Ragab Abdel-Gawad, Manal S. Fawzy
    Image of study
    TLDR The AIRE gene variant rs2075876 is linked to a higher risk of alopecia areata in males.
    The study investigated the association between the AIRE gene variant rs2075876 and alopecia areata (AA) in 337 males (97 AA patients and 240 controls). The GG genotype of rs2075876 was significantly more frequent in AA patients (90.7%) compared to controls (32.5%), with various genetic models showing increased risk for AA (e.g., OR = 16.1 for GG vs. AA). However, AIRE gene expression levels did not differ significantly between patients and controls and were not related to the rs2075876 variant. The intronic variant rs2075876 was suggested to be a potent susceptibility variant for AA development in the studied population.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 6 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Related Research

    2 / 2 results