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GlossaryKeratin 17

protein crucial for skin, hair, and nail structure

Keratin 17 (K17) is a type of protein found in the skin, hair follicles, and nails, playing a crucial role in their structural integrity and resilience. It is also involved in cellular processes like growth and repair, and its abnormal expression is linked to certain skin disorders and cancers.

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research The Autoimmune Regulator (AIRE), Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17

24 citations, February 2011 in “The American journal of pathology”

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

139 citations, December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

K6hf is a unique protein found only in a specific layer of hair follicles.

The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

70 citations, December 2004 in “Differentiation”

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression, with Alopecia Areata in Males: A Case-Control Study

research Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression, with Alopecia Areata in Males: A Case-Control Study

8 citations, October 2019 in “Immunological investigations”

The AIRE gene variant rs2075876 is linked to a higher risk of alopecia areata in males.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations, May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

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