3D-Printed Degradable Hair Follicle Hanging Drop Scaffolds Integrated With Tissue Engineered Skin Promotes Hair Follicle Regeneration In Vitro

    February 2025 in “ International Journal of Bioprinting ”
    Bin Yao, Yuhong Wang, Dongzhen Zhu, Tian Hu, Sha Huang, Ping Zhu
    TLDR 3D-printed scaffolds help regenerate hair follicles in lab-grown skin.
    The study explores the use of 3D-printed degradable scaffolds made from sodium alginate/gelatin/alginate lyase hydrogel to promote hair follicle regeneration in vitro. These scaffolds, integrated with tissue-engineered skin, provide a supportive microenvironment for hair follicle development, showing high expression of hair follicle-specific markers like LIM homeobox 2 (LHX2) and cytokeratin 17 (CK17). The research highlights the potential of this novel approach to create artificial skin with appendages, addressing limitations of current tissue-engineered skin products, such as poor long-term viability and lack of appendages. This advancement could offer a promising therapeutic option for patients with skin defects.
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