The Epithelial Stem Cell Niche in Skin
January 2017
in “
Elsevier eBooks
”
epithelial stem cells skin regeneration epidermis hair follicle sebaceous gland sweat gland stem cell niche extracellular matrix stem cell function mouse genetic models in vivo imaging stem cell populations hierarchical organization signaling pathways TGFß signaling EGFR signaling stem cell isolation molecular characterization therapeutic applications skin disorders skin injuries skin stem cells skin repair skin layers hair roots oil gland stem cell environment ECM stem cell roles mouse models live imaging stem cell groups stem cell hierarchy cell signaling TGF-beta signaling epidermal growth factor receptor signaling stem cell extraction molecular profiling treatment uses skin conditions skin damage
TLDR Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.
The document from January 1, 2017, provides a comprehensive overview of epithelial stem cells in the skin, detailing their roles in regeneration and maintenance across various skin structures such as the epidermis, hair follicle, sebaceous gland, and sweat gland. It emphasizes the significance of the stem cell niche, which comprises neighboring cells and noncellular components like the extracellular matrix, for supporting skin regeneration and maintaining cellular integrity. The paper discusses the challenges in engineering human skin substitutes, the advances in understanding stem cell function through mouse genetic models and in vivo imaging, and the distinct stem cell populations and their hierarchical organization. It also outlines the signaling pathways involved in stem cell regulation, including TGFß and EGFR signaling, and the variation in stem cell behavior depending on body location. The document concludes that these findings are vital for stem cell isolation and molecular characterization, which could lead to therapeutic applications for skin disorders and injuries.
