The Epithelial Stem Cell Niche in Skin

    January 2017 in “ Elsevier eBooks ”
    Géraldine Guasch
    Image of study
    TLDR Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.
    The document from January 1, 2017, provides a comprehensive overview of epithelial stem cells in the skin, detailing their roles in regeneration and maintenance across various skin structures such as the epidermis, hair follicle, sebaceous gland, and sweat gland. It emphasizes the significance of the stem cell niche, which comprises neighboring cells and noncellular components like the extracellular matrix, for supporting skin regeneration and maintaining cellular integrity. The paper discusses the challenges in engineering human skin substitutes, the advances in understanding stem cell function through mouse genetic models and in vivo imaging, and the distinct stem cell populations and their hierarchical organization. It also outlines the signaling pathways involved in stem cell regulation, including TGFß and EGFR signaling, and the variation in stem cell behavior depending on body location. The document concludes that these findings are vital for stem cell isolation and molecular characterization, which could lead to therapeutic applications for skin disorders and injuries.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 24 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community This is the best time in human history to be fighting hair loss

      in Treatment  193 upvotes 2 years ago
      This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

    Similar Research

    5 / 1000+ results