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    Glossary EGFR Signaling

    EGFR signaling refers to the pathway activated by the epidermal growth factor receptor (EGFR), a cell surface protein that plays a crucial role in cell proliferation, differentiation, and survival. In the context of hair biology, EGFR signaling is significant as it influences hair follicle development and cycling, particularly in the anagen (growth) phase. Dysregulation of this pathway can contribute to hair loss conditions, such as androgenetic alopecia, by affecting the health and function of hair follicles. Key distinguishing characteristics of EGFR signaling include its involvement in various cellular processes and its potential as a therapeutic target for hair restoration treatments.

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    1. LPA-producing enzyme PA-PLA<sub>1</sub>α regulates hair follicle development by modulating EGFR signalling The EMBO Journal · 2011 · 151 citations
    2. EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals Developmental Biology · 2012 · 53 citations
    3. 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line Journal of Investigative Dermatology · 2019
    4. Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling? Journal of Cellular Physiology · 2008 · 19 citations
    5. KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin Development · 2009 · 82 citations
    6. Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development Molecular Biology of the Cell · 2018 · 25 citations
    7. Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways International Journal of Molecular Sciences · 2024 · 3 citations
    8. A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling iScience · 2023 · 1 citations
    9. 176 Hair eruption initiates adverse events of EGFR-targeted cancer therapy Journal of Investigative Dermatology · 2023
    10. Integrin signalling regulates YAP/TAZ to control skin homeostasis Development · 2016 · 266 citations
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