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    Glossary EGFR Signaling

    EGFR signaling refers to the pathway activated by the epidermal growth factor receptor (EGFR), a cell surface protein that plays a crucial role in cell proliferation, differentiation, and survival. In the context of hair biology, EGFR signaling is significant as it influences hair follicle development and cycling, particularly in the anagen (growth) phase. Dysregulation of this pathway can contribute to hair loss conditions, such as androgenetic alopecia, by affecting the health and function of hair follicles. Key distinguishing characteristics of EGFR signaling include its involvement in various cellular processes and its potential as a therapeutic target for hair restoration treatments.

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    1. LPA-producing enzyme PA-PLA<sub>1</sub>α regulates hair follicle development by modulating EGFR signalling The EMBO Journal · 2011 · 151 citations
    2. EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals Developmental Biology · 2012 · 53 citations
    3. 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line Journal of Investigative Dermatology · 2019
    4. Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling? Journal of Cellular Physiology · 2008 · 19 citations
    5. KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin Development · 2009 · 82 citations
    6. Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development Molecular Biology of the Cell · 2018 · 25 citations
    7. Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways International Journal of Molecular Sciences · 2024 · 3 citations
    8. A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling iScience · 2023 · 1 citations
    9. 176 Hair eruption initiates adverse events of EGFR-targeted cancer therapy Journal of Investigative Dermatology · 2023
    10. Integrin signalling regulates YAP/TAZ to control skin homeostasis Development · 2016 · 266 citations
    11. Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy Science Translational Medicine · 2019 · 41 citations
    12. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    13. 1422 Uncoupling desmosomal cadherin adhesion activates quiescent hair follicle stem cells and orchestrates self-organized regeneration through outside-in signaling Journal of Investigative Dermatology · 2023
    14. Papulopustular eruptions associated with EGFR-pathway-related targeted therapies: clinical spectrum, evidence boundaries, folliculocentric inflammation, and management considerations Frontiers in Oncology · 2026
    15. 59 Scarring alopecia is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege 2023
    16. Cutaneous consequences of inhibiting EGF receptor signaling in vivo: Normal hair follicle development, but retarded hair cycle induction and inhibition of adipocyte growth in EgfrWa5 mice Journal of Dermatological Science · 2010 · 32 citations
    17. The Epithelial Stem Cell Niche in Skin Elsevier eBooks · 2017 · 9 citations
    18. Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis Frontiers in genetics · 2019 · 6 citations
    19. Eyelash Trichomegaly: A Rare Presenting Feature of Systemic Lupus Erythematosus. PubMed · 2017 · 4 citations
    20. Recurrent inverse necrotizing infundibular crystalline folliculitis Journal of Cutaneous Pathology · 2024 · 1 citations
    21. Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of barrier function, the microbiome, and immunity EMBO Molecular Medicine · 2024
    22. 551 Nrf2 activation enhances cutaneous wound healing by expansion of hair follicle stem cell populations Journal of Investigative Dermatology · 2016
    23. Specific In Vivo Ablation of Lrig1-Positive Follicular Progenitor Cells Results in Sebaceous Gland Loss in Mice International Journal of Molecular Sciences · 2026
    24. Basal cell carcinoma — molecular biology and potential new therapies Journal of Clinical Investigation · 2012 · 146 citations
    25. Management of Dermatologic Toxicities Journal of the National Comprehensive Cancer Network · 2015 · 12 citations
    26. Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells BMC Genomic Data · 2022 · 1 citations
    27. Baicalin Against Androgenetic Alopecia: A Network Pharmacology Study 2025
    28. Lithium chloride-treated human umbilical cord mesenchymal stem cells-derived exsomes promote hair growth by regulating miR-146a-5p-wnt pathway Stem Cells Translational Medicine · 2025
    29. Clinical-Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome (PCOS) Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment Research Square (Research Square) · 2024
    30. 645 MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma Journal of Investigative Dermatology · 2016