ECM1 Modified HF-MSCs Targeting HSC Attenuate Liver Cirrhosis by Inhibiting the TGF-β/Smad Signaling Pathway

    February 2022 in “ Cell Death Discovery ”
    Qi Liu, Chengqian Lv, Qianqian Huang … Shizhu Jin
    Studysummary In this study, researchers found that hair follicle-derived mesenchymal stem cells, modified to overexpress extracellular matrix protein 1, significantly improved liver function and reduced liver damage in cirrhotic mice by inhibiting hepatic stellate cell activation and TGF-β/Smad signaling.
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    Research cited in this study 3

    1. Mesenchymal Stem Cell Therapy for Liver Disease: Full of Chances and Challenges Cell & Bioscience · 2020
    2. Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells Stem Cell Research · 2011
    3. Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin Physiological Genomics · 2004