From Hair to Liver: Emerging Application of Hair Follicle Mesenchymal Stem Cell Transplantation Reverses Liver Cirrhosis by Blocking the TGF-β/Smad Signaling Pathway to Inhibit Pathological HSC Activation

    February 2022 in “ PeerJ ”
    Qi Liu, Chengqian Lv, Yanan Jiang … Shizhu Jin
    Studysummary This study found that hair follicle mesenchymal stem cells improved liver function and pathology in a mouse model of liver cirrhosis, potentially by inhibiting the TGF-β/Smad pathway and reducing hepatic stellate cell activation.
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    Research cited in this study 5

    1. From Hair to Pancreas: Transplanted Hair Follicle Mesenchymal Stem Cells Express Pancreatic Progenitor Cell Markers in a Rat Model of Acute Pancreatitis PubMed · 2021
    2. Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type 1 Diabetes Cell transplantation · 2014
    3. Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells Stem Cell Research · 2011
    4. Hair Follicle-Derived Smooth Muscle Cells and Small Intestinal Submucosa for Engineering Mechanically Robust and Vasoreactive Vascular Media Tissue Engineering Part A · 2010
    5. Effect of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Nanofiber Matrices Cocultured With Hair Follicular Epithelial and Dermal Cells for Biological Wound Dressing Artificial Organs · 2007

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