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GlossarySMAD signaling (SMAD pathway)

cellular process transmitting signals from surface to nucleus

SMAD signaling, also known as the SMAD pathway, is a cellular process that transmits signals from the cell surface to the nucleus in response to transforming growth factor-beta (TGF-β) and related cytokines. This pathway involves SMAD proteins, which are activated by receptor kinases and then move into the nucleus to regulate gene expression. This signaling is crucial for various biological processes, including cell growth, differentiation, and development, and has implications in conditions like cancer and fibrosis.

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research From Hair to Liver: Emerging Application of Hair Follicle Mesenchymal Stem Cell Transplantation Reverses Liver Cirrhosis by Blocking the TGF-β/Smad Signaling Pathway to Inhibit Pathological HSC Activation

4 citations , February 2022 in “PeerJ”

Hair follicle stem cell transplants can reverse liver cirrhosis by blocking harmful cell activation.

research The 800-nm Diode Laser Irradiation Induces Skin Collagen Synthesis by Stimulating TGF-β/Smad Signaling Pathway

59 citations , September 2011 in “Lasers in Medical Science”

The 800-nm laser boosts skin collagen production, improving skin structure.

research Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

139 citations , May 2020 in “Stem Cell Research & Therapy”

Exosomes from stem cells help wounds heal faster by affecting specific cell signals.

research ECM1 Modified HF-MSCs Targeting HSC Attenuate Liver Cirrhosis by Inhibiting the TGF-β/Smad Signaling Pathway

18 citations , February 2022 in “Cell Death Discovery”

ECM1-modified stem cells can effectively treat liver cirrhosis.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

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community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 1 month ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

in Research/Science 307 upvotes 8 months ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.

community 18m 2.5 mg dut + topical min + 5 mg injectable ghk-cu progress. caught agressive loss early seemingly. may i have a few more years of handsomeness upon me.

in Is this regrowth? 24 upvotes 5 months ago

An 18-year-old is using a high-dose treatment for hair loss, including 2.5 mg dutasteride, topical minoxidil, and injectable GHK-Cu, despite minimal hair loss. Many users suggest reducing the dutasteride dose due to potential side effects and recommend starting with finasteride instead.

community Male pattern baldness, and mental health

in Finasteride/Dutasteride 332 upvotes 1 year ago

A 48-year-old man has been using minoxidil for 15 years and considered finasteride but stopped due to potential side effects. He is concerned about his mental health and the impact of hair loss on self-image, and he encourages support among men experiencing hair loss.

community How do athletes maintain their hair transplants? Or do they not?

in Transplants 57 upvotes 1 year ago

Athletes often use finasteride to maintain hair transplants, but some avoid it due to potential hormonal effects. Notable examples include Mo Salah and Conor McGregor, while LeBron James has had multiple procedures with varying success.

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