HtrA1L364P Leads to Cognitive Dysfunction and Vascular Destruction Through TGF-β/Smad Signaling Pathway in CARASIL Model Mice

    July 2022 in “ Brain and Behavior ”
    Chuanfen Li, Xiaoling Wang, Jing Wen … Min Wang
    Studysummary This study observed that a CARASIL mouse model demonstrated abnormal behavior, vascular and cellular changes, and upregulation of the TGF-β/Smad signaling pathway, indicating its potential involvement in CARASIL pathogenesis.
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    Research cited in this study 2

    1. HtrA1L364P Leads to Cognitive Dysfunction and Vascular Destruction Through TGF-β/Smad Signaling Pathway in CARASIL Model Mice Brain and Behavior · 2022
    2. CXXC5: A Novel Regulator and Coordinator of TGF-β, BMP, and Wnt Signaling Journal of Cellular and Molecular Medicine · 2018