Exosomal MicroRNA-Based Therapies for Skin Diseases

Exosomal microRNA (miRNA)-based therapies show promising therapeutic effects on various skin diseases, including hair loss, in animal models. These therapies, particularly those using miRNA-overexpressing exosomes, demonstrated superior efficacy compared to natural exosomes. Key findings include miR-122-5p promoting hair growth by counteracting dihydrotestosterone's effects on dermal papilla cells in a study with 30 mice. Other miRNAs, such as miR-126-3p, miR-135a, and miR-146a, enhance wound healing, reduce inflammation, and improve skin regeneration. The review emphasizes the need for further clinical trials to validate these findings and compares the effectiveness of miRNA therapies with standard treatments.