Extracellular Vesicles in Age-Related Diseases: Disease Pathogenesis, Intervention, and Biomarker

    May 2025 in “ Stem Cell Research & Therapy ”
    Puan Haliza Lintang Putri, Samira Husen Alamudi, Xuan Dong, Ying Fu
    Studysummary This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.
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    Research cited in this study 11

    1. Combating Aging in Dermal Papilla Cells and Promoting Hair Follicle Regeneration Using Exosomes from Human Hair Follicle Dermal Sheath Cup Cells Experimental Dermatology · 2023
    2. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway Stem Cells International · 2023
    3. Androgenetic Alopecia: An Update JAAD International · 2023
    4. Androgenetic Alopecia: Therapy Update Drugs · 2023
    5. Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    6. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    7. Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway International journal of biological macromolecules · 2022
    8. Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100 Journal of nanobiotechnology · 2021
    9. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    10. Inflammatory Priming Enhances Mesenchymal Stromal Cell Secretome Potential as a Clinical Product for Regenerative Medicine Approaches Through Secreted Factors and EV-miRNAs: The Example of Joint Disease Stem Cell Research & Therapy · 2020
    11. Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation International journal of biological sciences · 2019