Inflammatory Priming Enhances Mesenchymal Stromal Cell Secretome Potential as a Clinical Product for Regenerative Medicine Approaches Through Secreted Factors and EV-miRNAs: The Example of Joint Disease

    April 2020 in “ Stem Cell Research & Therapy ”
    Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca … Laura de Girolamo
    Studysummary This study found that adipose-derived mesenchymal stromal cell secretome, particularly when preconditioned with IFNγ, significantly influences cell motility and anti-inflammatory responses, enhancing its potential as a regenerative therapy.
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    Research cited in this study 4

    1. Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome Cells · 2019
    2. Proteomic Analysis of Human Mesenchymal Stromal Cell Secretomes: A Systematic Comparison of the Angiogenic Potential npj Regenerative Medicine · 2019
    3. Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-Conditioning Frontiers in Immunology · 2018
    4. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015