Combating Aging in Dermal Papilla Cells and Promoting Hair Follicle Regeneration Using Exosomes from Human Hair Follicle Dermal Sheath Cup Cells

November 2023 in “ Experimental Dermatology ”

Fang Liu, Si Liu, Xiaohua Luo, Zhexiang Fan, Shaobin Huang, Fei Deng, Huanliang Liu, Ge Shi

exosomes Dermal Sheath Cup Cells ExoDSCCs Dermal Papilla Cells DPCs androgenetic alopecia senescent alopecia SA-β-Gal Wnt/β-catenin signalling hair follicle reconstruction senile alopecia DSCCs androgenic alopecia aging hair loss senescence marker Wnt signaling hair follicle regeneration age-related hair loss

TLDR Exosomes from human hair follicle cells can improve aging hair follicle cell function and help regenerate hair follicles.

The research investigated the anti-ageing effect of exosomes derived from Dermal Sheath Cup Cells (ExoDSCCs) on Dermal Papilla Cells (DPCs), which undergo premature ageing in androgenetic alopecia and senescent alopecia. The study found that ExoDSCCs promote the proliferation, viability, and migration of senescent DPCs while inhibiting cell apoptosis. The expression of the senescence marker SA-β-Gal was significantly downregulated in senescent DPCs treated with ExoDSCCs. Additionally, ExoDSCCs activated the Wnt/β-catenin signalling in vitro and significantly promoted hair follicle reconstruction in senescent DPCs. The findings suggest that ExoDSCCs may restore the biological functions and improve the hair follicle induction ability of senescent DPCs, potentially offering a new strategy for intervening in the ageing process of DPCs and preventing senile alopecia.

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