Combating Aging in Dermal Papilla Cells and Promoting Hair Follicle Regeneration Using Exosomes from Human Hair Follicle Dermal Sheath Cup Cells

November 2023 in “ Experimental Dermatology ”

Fang Liu, Si Liu, Xiaohua Luo, Zhexiang Fan, Shaobin Huang, Fei Deng, Huanliang Liu, Ge Shi

exosomes Dermal Sheath Cup Cells ExoDSCCs Dermal Papilla Cells DPCs androgenetic alopecia senescent alopecia SA-β-Gal Wnt/β-catenin signalling hair follicle reconstruction senile alopecia DSCCs androgenic alopecia aging hair loss senescence marker Wnt signaling hair follicle regeneration age-related hair loss

TLDR Exosomes from human hair follicle cells can improve aging hair follicle cell function and help regenerate hair follicles.

The research investigated the anti-ageing effect of exosomes derived from Dermal Sheath Cup Cells (ExoDSCCs) on Dermal Papilla Cells (DPCs), which undergo premature ageing in androgenetic alopecia and senescent alopecia. The study found that ExoDSCCs promote the proliferation, viability, and migration of senescent DPCs while inhibiting cell apoptosis. The expression of the senescence marker SA-β-Gal was significantly downregulated in senescent DPCs treated with ExoDSCCs. Additionally, ExoDSCCs activated the Wnt/β-catenin signalling in vitro and significantly promoted hair follicle reconstruction in senescent DPCs. The findings suggest that ExoDSCCs may restore the biological functions and improve the hair follicle induction ability of senescent DPCs, potentially offering a new strategy for intervening in the ageing process of DPCs and preventing senile alopecia.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

27 / 27 results

research Update on Exosomes in Aesthetics

3 citations , May 2022 in “Dermatologic surgery”

Exosomes could help with skin and hair, but more research and better methods are needed.

research Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway

25 citations , March 2022 in “International journal of biological macromolecules”

miR-181a-5p helps hair growth by activating a specific signaling pathway.

research Effects of Exosomes from Adipose-Derived Stem Cells on Hair Loss: A Retrospective Analysis of 39 Patients

10 citations , February 2022 in “Journal of cosmetic dermatology”

Exosomes from fat-derived stem cells may help regrow hair.

research Clinical Use of Extracellular Vesicles in the Management of Male and Female Pattern Hair Loss: A Preliminary Retrospective Institutional Review Board Safety and Efficacy Study

January 2022 in “Aesthetic surgery journal”

Extracellular vesicles may effectively treat hair loss with minimal side effects.

Towards Developing an Organotypic Model for the Preclinical Study and Manipulation of Human Hair Matrix-Dermal Papilla Interactions

research Towards Developing an Organotypic Model for the Preclinical Study and Manipulation of Human Hair Matrix-Dermal Papilla Interactions

4 citations , January 2021 in “Archives of dermatological research”

The study created a new model to better understand human hair growth and health.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

65 citations , July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia

39 citations , March 2019 in “Dermatologic Surgery”

PRP therapy increases hair density for androgenetic alopecia.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , April 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

research Aging in Hair Follicle Stem Cells and Niche Microenvironment

38 citations , June 2017 in “The Journal of Dermatology”

Aging in hair follicle stem cells leads to hair graying, thinning, and loss.

research Hair Follicle Dermal Stem Cells and Skin-Derived Precursor Cells: Exciting Tools for Endogenous and Exogenous Therapies

30 citations , April 2017 in “Experimental Dermatology”

Hair follicle stem cells and skin cells show promise for hair and skin therapies but need more research for clinical use.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction

35 citations , January 2017 in “Journal of Dermatological Science”

Stress can cause early aging in certain skin cells, leading to problems with hair growth.

Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

research Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

46 citations , April 2016 in “Journal of Investigative Dermatology”

New genes found linked to balding, may help develop future treatments.

research Aging Hair Follicles Rejuvenated by Transplantation to a Young Subcutaneous Environment

11 citations , March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

Old hair follicles grew better when moved to a young environment.

research Dermal Sheath Cells Contribute to Postnatal Hair Follicle Growth and Cycling

10 citations , February 2016 in “Journal of Dermatological Science”

Skin sheath cells help in hair growth and renewal after birth.

research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis

242 citations , February 2016 in “Science”

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

research In Vitro Characterization of Human Hair Follicle Dermal Sheath Mesenchymal Stromal Cells and Their Potential in Enhancing Diabetic Wound Healing

52 citations , May 2015 in “Cytotherapy”

DS-MSCs from hair follicles may improve diabetic wound healing.

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

Oxidative stress affects hair loss in men with androgenetic alopecia.

research Age-Related Hair Changes in Men: Mechanisms and Management of Alopecia and Graying

37 citations , October 2014 in “Maturitas”

Men's hair loss is caused by hormones and genes, and can be treated with medication and surgery, while graying is due to aging and has no prevention except dyeing.

Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

research Arctiin Blocks Hydrogen Peroxide-Induced Senescence and Cell Death Through MicroRNA Expression Changes in Human Dermal Papilla Cells

25 citations , September 2014 in “Biological Research”

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4

75 citations , March 2014 in “Journal of Investigative Dermatology”

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

research Neonatal Murine Skin-Derived Cells Transplanted Using a Mini-Chamber Model Produce Robust and Normal Hair

9 citations , August 2013 in “Journal of Tissue Engineering and Regenerative Medicine”

Transplanted baby mouse skin cells grew normal hair using a new, efficient method.

research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

330 citations , December 2009 in “Cell stem cell”

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

53 citations , January 2009 in “Journal of Investigative Dermatology”

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research Association Between Smoking and Hair Loss: Another Opportunity for Health Education Against Smoking?

102 citations , January 2003 in “Dermatology”

Smoking may contribute to hair loss in men.

Related Research

6 / 6 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations , April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.