Aging Hair Follicles Rejuvenated by Transplantation to a Young Subcutaneous Environment

    March 2016 in “ Cell cycle/Cell cycle (Georgetown, Tex. Online) ”
    Wenluo Cao, Lingna Li, Satoshi Kajiura, Yasuyuki Amoh, Yuying Tan, Fang Liu, Robert M. Hoffman
    TLDR Old hair follicles grew better when moved to a young environment.
    The study demonstrated that transplanting aged hair follicles into young host mice rejuvenated the follicles and promoted hair shaft growth, unlike transplants into old host mice, which did not support hair growth. The activity of nestin-expressing hair follicle-associated pluripotent (HAP) stem cells remained high in young hosts but was reduced in old hosts. The research involved 4 groups of hair follicles (17-20 follicles per group) and suggested that the young subcutaneous environment could reverse aging in hair follicles, indicating that hair loss due to aging might be reversible. The findings highlighted the potential for using this model to test hair-growth promoting drugs and explore the role of stem cells and pharmaceutical interventions in rejuvenating aging hair follicles.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community Anyone who is not taking fin after hair transplant, how is you hair now?

      in Transplants  81 upvotes 1 year ago
      The conversation is about the effectiveness of finasteride (fin) in preventing hair loss after a hair transplant. Some users have experienced hair thinning and loss after stopping finasteride, while others have had success with finasteride and minoxidil (min) in maintaining their transplanted hair. The general consensus is that finasteride is important for younger patients to prevent further hair loss.

      community Hair Cloning, Trials were supposed to begin 2020-2021

      in Technology  48 upvotes 4 years ago
      The conversation discusses hair cloning trials expected to start in 2020-2021 and mentions concerns about potential delays due to the Coronavirus. Treatments like Minoxidil, finasteride, and RU58841 are referenced.
      [object Object]

      community Verteporfin and Microneedling

      in Treatments 7 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  828 upvotes 5 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Similar Research

    5 / 1000+ results