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Did you mean Hair Follicle Aging?

Glossary Hair Follicle Aging

gradual decline in hair follicle function and structure over time

Hair Follicle Aging refers to the gradual decline in the function and structure of hair follicles over time. This process can lead to thinner, weaker hair, slower growth rates, and eventually hair loss. Factors contributing to hair follicle aging include genetic predisposition, hormonal changes, oxidative stress, and reduced cellular regeneration.

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Research

5 / 1000+ results

research Aging in hair follicle stem cells and niche microenvironment

38 citations , June 2017 in “The Journal of Dermatology”

This review synthesizes recent findings on the hair follicle stem cell niche and its complex interactions, exploring potential pathways for developing new hair growth therapies; it reports no new clinical results.

research Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment

11 citations , March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

This study found that young host mice rejuvenated aged hair follicles after transplantation, while aged host mice did not support hair growth from transplanted follicles.

research Editorial: Hair Follicle Stem Cell Regeneration in Aging

4 citations , November 2021 in “Frontiers in Cell and Developmental Biology”

Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.

research Aging of hair follicle stem cells and their niches

2 citations , November 2022 in “Journal of Biochemistry and Molecular Biology”

This review discusses how aging affects hair follicle stem cells and their environment, contributing to hair loss, and explores strategies to promote hair regrowth, but reports no new results.

research An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging

12 citations , December 2021 in “Aging”

This study demonstrated that a new non-invasive method for collecting and analyzing mouse hair follicles could replace traditional biopsy methods, providing advantages for translational research and routine applications.

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Community Join

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community Baldness Breakthrough: microRNA Stimulates Hair Growth in Aging Follicles

316 upvotes 3 years ago

miR-205, a tiny RNA, can stimulate hair growth by softening aging hair follicle stem cells in mice. Future tests aim to see if this can work in humans.

community Anyone here have a lot of knowledge on hair follicle stem cells and progenitor cells for PP405?

in Chat 4 upvotes 8 months ago

Hair follicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.

community If PP405 does revive "dead" hair follicles would DHT blockers theoretically be enough to maintain that new hair

in Research/Science 115 upvotes 11 months ago

PP405 may revive dormant hair follicles, and DHT blockers like finasteride or dutasteride could maintain new hair. Combining PP405 with minoxidil might be optimal, but long-term effects and continuous use are uncertain.

community Intermittent fasting triggers hair loss in study (suppresses hair follicle regeneration)

in Research/Science 241 upvotes 8 months ago

Intermittent fasting may suppress hair follicle regeneration, but opinions vary on its impact on hair loss. Some users report no negative effects or even hair improvement while using treatments like finasteride and minoxidil.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

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Learn

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

learn Dexpanthenol

precursor of vitamin B5 with hair stimulating effects

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Overview

learn Hair Transplant

Is a hair transplant permanent? Transplanted hair is generally permanent but requires ongoing care to maintain results.

learn PP405

Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

learn KY19382

How does KY19382 actually stimulate dormant hair follicles to grow again? KY19382 stimulates dormant hair follicles by reactivating the Wnt/β-catenin signaling pathway.

learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

learn GHK-Cu

Heard alopecia areata leaves scar-like spots? Some peptides are helping those areas regrow hair. Alopecia areata patches usually still have living follicles. Peptides are being studied as a possible add-on, but the evidence is small and early. See a dermatologist for treatment.

Clinics

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All 39 clinic results →

Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas