Comparison of Calcium and Barium Microcapsules as Scaffolds in the Development of Artificial Dermal Papillae

    January 2016 in “ BioMed research international ”
    Yang Liu, Cheng Huang Lin, Yang Zeng, Haihong Li, Bin Cai, Keng Huang, Yanping Yuan, Yu Liu
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    TLDR Calcium microcapsules are better for long-term use in artificial dermal papilla, while barium microcapsules are good for short-term.
    The study from 2016 investigated the use of barium and calcium microcapsules as scaffolds for artificial dermal papilla, which are structures at the base of hair follicles. Dermal papilla cells were cultured and encapsulated using a high-voltage electric-field droplet generator, and the resulting microcapsules were transplanted into rat ears to assess their effectiveness. Both types of microcapsules successfully maintained the cells and induced hair follicle formation. However, calcium microcapsules demonstrated superior biocompatibility, permeability, and cell viability, although they showed signs of immune response and fibrous wrapping after 32 weeks. Barium microcapsules had better structural and mechanical stability and higher short-term cell viability. The study concluded that calcium microcapsules could be effective scaffolds for long-term artificial dermal papilla development, while barium microcapsules might be more suitable for short-term transplantation studies.
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