Nerve Growth Factor and Burn Wound Healing: Update of Molecular Interactions With Skin Cells
August 2023
in “
Burns
”
Nerve Growth Factor NGF neurotrophins burn wound healing homeostasis phase inflammatory phase proliferative phase remodeling phase skin cells nervous system immune cells signaling molecules pathways fibrotic tissue disorders wound healing diabetic peripheral neuropathies nerve growth factor burn healing fibrotic tissue diabetic neuropathy
TLDR Nerve growth factor helps improve healing time and scar quality in burn wounds.
The document discusses the role of Nerve Growth Factor (NGF) in burn wound healing. NGF, a protein belonging to the neurotrophins class, is produced by various cell lines and plays a crucial role in the healing process. The healing process involves three overlapping stages: homeostasis/inflammatory phase, proliferative phase, and remodeling phase. NGF regulates the interaction between all types of skin cells, including the nervous system and immune cells, through complex signaling molecules and pathways. However, overexpression of NGF can lead to fibrotic tissue disorders, while its downregulation can delay wound healing. The therapeutic benefits of NGF have been explored in diabetic patients affected by peripheral neuropathies and in a wide range of other applications. The use of NGF in wound healing, particularly burn wound healing, appears promising.
