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Glossary Inflammatory Phase

body's initial response to injury involving immune system activation

The Inflammatory Phase is the initial stage of the wound healing process, where the body's immune system responds to injury. During this phase, which typically lasts a few days, white blood cells, growth factors, and nutrients are sent to the wound site to fight infection, remove debris, and prepare for tissue repair. This phase is crucial for preventing infection and setting the stage for subsequent healing phases.

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Research

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Pea Sprout Extract Promotes Hair Follicle Regeneration Via Anagen Phase Prolongation And Dual Modulation Of Oxidative And Inflammatory Signaling

research Pea Sprout Extract Promotes Hair Follicle Regeneration via Anagen Phase Prolongation and Dual Modulation of Oxidative and Inflammatory Signaling

November 2025 in “Journal of Microbiology and Biotechnology”

This study demonstrates that pea sprout extract promotes hair growth by activating specific signaling pathways and providing antioxidant and anti-inflammatory effects, suggesting its potential as a natural alopecia treatment.

research Local anti-inflammatory effect and immunomodulatory activity of chitosan-based dressing in skin wound healing: a systematic review

4 citations , November 2022 in “Journal of clinical and translational research”

This systematic review found that chitosan-based wound therapy may accelerate wound healing by reducing inflammation and modulating immune response, but notes limited clinical trials to date.

research A phase 2a trial of brepocitinib for cicatricial alopecia

17 citations , October 2024 in “Journal of the American Academy of Dermatology”

In this study, brepocitinib was found to significantly reduce inflammatory biomarker CCL5 expression and improve clinical severity by week 24, while maintaining a favorable safety profile.

research Effect of Free Long-Chain Fatty Acids on Anagen Induction: Metabolic or Inflammatory Aspect?

March 2025 in “International Journal of Molecular Sciences”

This study observed that topical application of palmitate or oleate accelerated the onset of the hair growth phase in mice, whereas glycolysis end product lactate delayed it, suggesting metabolic regulation as a promising approach for influencing hair growth.

Gas Chromatography Coupled to Mass Spectrometry Characterization, Anti-Inflammatory Effect, Wound-Healing Potential, and Hair Growth-Promoting Activity of Algerian Carthamus Caeruleus L (Asteraceae)

research Gas chromatography coupled to mass spectrometry characterization, anti-inflammatory effect, wound-healing potential, and hair growth-promoting activity of Algerian Carthamus caeruleus L (Asteraceae)

7 citations , May 2018 in “Indian Journal of Pharmacology”

This study found that the methanolic extract of Carthamus caeruleus roots significantly reduced inflammation, promoted wound healing, and enhanced hair growth in experimental models, supporting its traditional use in Northern Algeria as a skincare remedy.

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Community Join

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community Forgotten Hair Loss Peptide by L'Oreal: KPV

5 upvotes 2 years ago

KPV, a peptide patented by L'Oreal, may promote hair growth and reduce hair loss by extending the anagen phase and has anti-inflammatory properties. It could be combined with treatments like minoxidil for enhanced effects.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 7 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

community Rosemary Oil for inflammatory hairloss? Recommendations?

5 upvotes 1 year ago

A user with seborrheic dermatitis and traction alopecia is seeking alternatives to minoxidil for hair loss, considering rosemary oil for its anti-inflammatory properties. They express concerns about potential side effects and effectiveness of various treatments, including rosemary oil, caffeine, and Redensyl.

community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

276 upvotes 6 months ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

110 upvotes 2 years ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

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Learn

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learn Low Level Laser Therapy

laser therapy for anti-inflammatory and likely insignificant hair regrowth effects

learn HMI-115

much-hyped research compound targeting prolactin receptor in scalp

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn sh-Polypeptide-7

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

learn capsicum

Is capsicum safe for sensitive scalps or inflammatory hair loss? Capsicum may irritate sensitive scalps and worsen inflammatory hair loss.

learn Cetirizine

What makes cetirizine a unique anti-inflammatory option for your scalp? Laboratory work reports that cetirizine lowers PGD2 and other inflammatory mediators, which is why researchers have proposed it for the scalp. There is no approved topical product and the clinical evidence is one small unblinded pilot study in pattern hair loss, so scalp use is off-label and experimental.

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