Effect of Epidermal Growth Factor and Platelet-Rich Plasma in Experimental Rat Burn Model

June 2023 in “ Zenodo (CERN European Organization for Nuclear Research) ”

Abdülkadir Calavul

epidermal growth factor platelet-rich plasma hair follicle regeneration EGF PRP

TLDR PRP and EGF speed up healing in severe rat burns.

This study investigated the effects of platelet-rich plasma (PRP) and epidermal growth factor (EGF) on burn wounds in 48 male Spraque-Dawley rats. The rats were divided into four groups: a control group, a group treated with EGF, a group treated with EGF + PRP, and a group treated with PRP. The results showed statistically significant improvements in epidermis regeneration, granulation, inflammation, and hair follicle regeneration in the treated groups compared to the control group over 21 days. The study concluded that PRP and EGF positively affected and accelerated wound healing in rats with third-degree burns.

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