Fractional CO₂ Laser Combined With Topical Compound Betamethasone for Vitiligo-Associated Leukotrichia: A Retrospective Study of 13 Patients With Limited Effectiveness

    February 2026
    Xuhai Yuan, Juan Du, Xinxin Li … Fang Wang
    Studysummary In this study involving 13 patients with vitiligo-associated leukotrichia, minimal hair repigmentation was observed following treatment with fractional CO₂ laser and topical betamethasone, though the method was well tolerated, highlighting the need for further research to optimize treatment parameters.
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    Research cited in this study 10

    1. Pathogenesis and Regenerative Therapy in Vitiligo and Alopecia Areata: Focus on Hair Follicle Frontiers in Medicine · 2025
    2. The Role of Laser and Energy-Assisted Drug Delivery in the Treatment of Alopecia Lasers in Medical Science · 2024
    3. A Prospective Study of Dermoscopic and Ultrastructural Features of Vitiligo-Associated Leukotrichia Clinical, cosmetic and investigational dermatology · 2023
    4. Minimally Invasive Removal of Leukotrichia and Hair Transplantation: A Two-Step Surgery in the Treatment of Stable Follicular Vitiligo Plastic & Reconstructive Surgery · 2023
    5. Effect of Fractional Laser Alone or in Combination on Alopecia Areata: A Systematic Review and Meta-Analysis Journal of cosmetic dermatology · 2023
    6. Evaluation of Fractional Carbon Dioxide Laser Alone Versus Its Combination With Betamethasone Valerate in Treatment of Alopecia Areata: A Clinical and Dermoscopic Study Archives of dermatological research · 2022
    7. Fractional-Assisted Drug Delivery Performed with Erbium YAG Laser in Androgenic Alopecia: Histological Aspects Dermatologic Therapy · 2021
    8. Comparative Study Between Fractional Carbon Dioxide Laser vs Intralesional Steroid Injection in Treatment of Alopecia Areata Dermatologic Therapy · 2020
    9. Effects of CO2 Fractional Laser on Hair Growth in C57BL/6 Mice and Potential Underlying Mechanisms Chinese Medical Journal · 2019
    10. Preservation of Melanoblasts in White Hair Follicles of Segmental Vitiligo Lesions: A Preliminary Study JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2010