Effects of CO2 Fractional Laser on Hair Growth in C57BL/6 Mice and Potential Underlying Mechanisms

May 2019 in “ Chinese Medical Journal ”

Fenglin Zhuo, Linfeng Li, Liangqi Cai, Yue Huang

CO2 fractional laser hair growth inflammatory cytokines Wnt signal pathway Wnt10b β-catenin ablative CO2 fractional laser therapy carbon dioxide fractional laser hair regrowth inflammatory proteins Wnt pathway beta-catenin

TLDR CO2 fractional laser therapy may help regrow hair without scarring by affecting certain inflammatory and growth-related molecules.

In 2019, a study involving 60 C57BL/6 mice investigated the effects of CO2 fractional laser on hair growth and the potential underlying mechanisms. The study found that the laser treatment induced hair re-growth and scar formation in a dose-dependent manner, with the most effective dosage being 18 mJ/spot and 361 spots/cm2, which promoted hair re-growth without causing scarring. The expression of several inflammatory cytokines and Wnt signal pathway molecules, including Wnt10b and β-catenin, increased after laser treatment, suggesting their role in hair re-growth. The study concluded that ablative CO2 fractional laser therapy could potentially serve as a supplementary or alternative treatment for hair loss.

View this study on journals.lww.com →

Discuss this study in the Community →

Cited in this study

9 / 9 results

research Fractional Non-Ablative Laser-Assisted Drug Delivery Leads to Improvement in Male and Female Pattern Hair Loss

15 citations , February 2018 in “Journal of Cosmetic and Laser Therapy”

Laser-assisted drug delivery improves hair loss.

research Aging in Hair Follicle Stem Cells and Niche Microenvironment

38 citations , June 2017 in “The Journal of Dermatology”

Aging in hair follicle stem cells leads to hair graying, thinning, and loss.

research Enhancing Hair Growth in Male Androgenetic Alopecia by a Combination of Fractional CO2 Laser Therapy and Hair Growth Factors

26 citations , May 2017 in “Lasers in Medical Science”

Laser therapy and hair growth factors significantly improve hair density in male baldness.

research Low-Level Laser Therapy as a Treatment for Androgenetic Alopecia

47 citations , January 2017 in “Lasers in Surgery and Medicine”

Low-level laser therapy may improve hair regrowth and thickness for androgenetic alopecia, but more research is needed.

research Enhancing Hair Follicle Regeneration by Nonablative Fractional Laser: Assessment of Irradiation Parameters and Tissue Response

16 citations , April 2015 in “Lasers in Surgery and Medicine”

Using a fractional laser can stimulate hair growth, but the intensity and duration of inflammation are crucial. Too much can cause ulcers and scarring. Lower beam energy and fewer treatments are recommended to avoid damage.

Effects of CO2 Fractional Laser on Hair Growth in C57BL/6 Mice and Potential Underlying Mechanisms

Cited in this study

research Fractional Non-Ablative Laser-Assisted Drug Delivery Leads to Improvement in Male and Female Pattern Hair Loss

research Aging in Hair Follicle Stem Cells and Niche Microenvironment

research Enhancing Hair Growth in Male Androgenetic Alopecia by a Combination of Fractional CO2 Laser Therapy and Hair Growth Factors

research Low-Level Laser Therapy as a Treatment for Androgenetic Alopecia

research Enhancing Hair Follicle Regeneration by Nonablative Fractional Laser: Assessment of Irradiation Parameters and Tissue Response

research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4

research Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

research New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis