Platelet-Rich Plasma in Interventional Dermatology and Trichology: How Far Have We Come?

June 2021 in “ Cosmoderma ”

Suruchi Garg, Anuva Bansal

platelet-rich plasma PRP wound healing angiogenesis skin rejuvenation hair follicles androgenetic alopecia AGA hair density hair count terminal hair density hair shedding hair diameter microneedling hair transplantation growth factors

TLDR Platelet-rich plasma (PRP) shows promise in skin and hair treatments but results vary with preparation methods.

Platelet-rich plasma (PRP) is a treatment derived from a patient's own blood that promotes wound healing, angiogenesis, and rejuvenation of skin and hair follicles. It has been used to treat various skin conditions, including scars, stretch marks, and chronic ulcers, and has shown promise in skin rejuvenation and the treatment of conditions like melasma and vitiligo. In trichology, PRP has been effective in treating androgenetic alopecia (AGA), with studies showing significant improvements in hair density, hair count, terminal hair density, hair shedding, and hair diameter. PRP has also been used in combination with other treatments, such as microneedling and hair transplantation. However, the effectiveness of PRP can vary depending on the method of preparation and the concentration of growth factors.

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research A Comparative Study of Therapeutic Response to Intralesional Injections of Platelet-Rich Plasma Versus Triamcinolone Acetonide in Alopecia Areata

8 citations , November 2020 in “Indian Dermatology Online Journal”

research Platelet-Rich Plasma in the Treatment of Alopecia Areata: A Review

15 citations , November 2020 in “Journal of Investigative Dermatology Symposium Proceedings”

Platelet-Rich Plasma (PRP) could potentially help regrow hair in people with Alopecia Areata, but more research is needed to confirm its effectiveness.

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research Platelet-Rich Plasma: The Journey So Far

18 citations , January 2020 in “Indian Dermatology Online Journal”

Platelet-rich plasma shows potential for hair loss and skin rejuvenation but needs more research for widespread use.

research Platelet-Rich Plasma for Treatment-Resistant Frontal Fibrosing Alopecia: A Case Report

15 citations , September 2019 in “Dermatologic Therapy”

Platelet-rich plasma (PRP) may help treat hair loss in patients with frontal fibrosing alopecia who don't respond to other treatments.

research Use of Platelet-Rich Plasma in Cicatricial Alopecia

28 citations , July 2019 in “Dermatologic Surgery”

Platelet-Rich Plasma (PRP) may help improve hair density in primary cicatricial alopecias (PCAs) patients, but more trials are needed to confirm its benefits.

research Platelet-Rich Plasma on Female Androgenetic Alopecia: Tested on 10 Patients

25 citations , February 2019 in “Journal of Cosmetic Dermatology”

PRP injections increase hair density and diameter in female androgenetic alopecia patients.

research Follicular Unit Extraction Hair Transplantation in Combination with Platelet Rich Plasma for the Treatment of Scarring Alopecia: A Case Series

4 citations , January 2019 in “Archives of clinical and medical case reports”

Combining FUE hair transplantation with PRP improves hair density and patient satisfaction in scarring alopecia.

research Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia Along with Dermoscopic Pre- and Post-Treatment Evaluation

36 citations , June 2018 in “Journal of Cosmetic Dermatology”

PRP with microneedling effectively treats hair loss, and dermoscopy helps evaluate results.

research Platelet-Rich Plasma Versus Tretinoin in Treatment of Striae Distensae: A Comparative Study

22 citations , May 2018 in “Dermatologic Surgery”

Platelet-rich plasma injections are more effective and satisfying for treating skin scars than tretinoin cream.

research The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

52 citations , February 2018 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

24 citations , January 2018 in “Journal of Visualized Experiments”

PRP injections effectively promote hair growth in androgenetic alopecia patients.

research Platelet-Rich Plasma—An 'Elixir' for Treatment of Alopecia: Personal Experience on 117 Patients with Review of Literature

31 citations , July 2017 in “Stem cell investigation”

Platelet-rich plasma (PRP) is a simple, cost-effective treatment that promotes hair growth and reduces hair loss, with high patient satisfaction.

research A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

348 citations , July 2017 in “Skin appendage disorders”

Platelet-rich plasma shows promise for skin and hair treatments but needs more research and standardization.

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

86 citations , June 2017 in “Stem cell investigation”

Stem cells from hair follicles can safely treat hair loss.

research The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study

70 citations , May 2017 in “Dermatologic Surgery”

Treatment with plasma rich in growth factors improved hair density and thickness for hair loss patients.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

3 citations , May 2017 in “Dermatologic Surgery”

PRP may help treat female hair loss, but more research needed.

research A Study of the Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia in Males

20 citations , May 2017 in “Indian Journal of Dermatology, Venereology and Leprology”

Platelet-rich plasma treatment significantly increased hair diameter and density, stopped hair fall, and boosted hair growth in men with hair loss, with no reported side effects.

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research Platelet-Rich Plasma Versus Minoxidil 5% in Treatment of Alopecia Areata: A Trichoscopic Evaluation

62 citations , January 2017 in “Dermatologic Therapy”

PRP more effective than minoxidil 5% for treating alopecia areata.

research A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia

60 citations , December 2016 in “Dermatologic Surgery”

PRP treatment may stimulate hair growth by promoting blood vessel formation, increasing growth factors, and preventing cell death.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations , November 2016 in “Dermatologic Surgery”

PRP shows potential for treating female hair loss, but more research needed.

research Using Automated Microneedling with Platelet-Rich Plasma for Treating Cicatricial Alopecia, Recalcitrant Alopecia Areata, and Traction Alopecia: Case Report

4 citations , May 2016 in “Journal of The American Academy of Dermatology”

Microneedling with platelet-rich plasma can improve different types of hair loss.

research Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

106 citations , January 2016 in “Journal of Cosmetic Dermatology”

Using platelet-rich plasma with microneedling works better for acne scars than microneedling with water.

research Successful Hair Transplant Outcome in Cicatricial Lichen Planus of the Scalp by Combining Scalp and Beard Hair Along with Platelet Rich Plasma

26 citations , January 2016 in “Journal of cutaneous and aesthetic surgery”

Hair transplant combining scalp and beard hair with PRP was successful for scarring alopecia.

research Outcome of Intra-Operative Injected Platelet-Rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomized Study in Forty Patients

39 citations , January 2016 in “Journal of Cutaneous and Aesthetic Surgery”

Injecting platelet-rich plasma during hair transplant surgery improves hair regrowth rate, speeds up skin recovery, and enhances hair quality.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

research Successful Treatment of Corticosteroid-Resistant Ophiasis-Type Alopecia Areata with Platelet-Rich Plasma

30 citations , September 2015 in “JAAD case reports”

Platelet-rich plasma (PRP) injections successfully treated a woman's steroid-resistant hair loss, causing hair to regrow within a month.

research Efficacy of Platelet-Rich Plasma in Treatment of Androgenic Alopecia

74 citations , July 2015 in “Asian Journal of Transfusion Science”

Platelet-rich plasma (PRP) injections can effectively increase hair density and thickness in people with androgenic alopecia, without major side effects.

research Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration

83 citations , May 2015 in “World Journal of Stem Cells”

Hair follicle regeneration needs special conditions and young cells.

research Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice

64 citations , January 2015 in “BioMed Research International”

Certain growth factors can promote hair growth in mice by activating hair growth-related proteins.

research Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool

115 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

Platelet-rich plasma (PRP) is a cheap and easy treatment for hair loss, but not suitable for everyone. It also helps in healing ulcers, rejuvenating skin, and improving hair transplants.

research Beyond Goosebumps: Does the Arrector Pili Muscle Have a Role in Hair Loss?

31 citations , January 2014 in “International Journal of Trichology”

The arrector pili muscle might play a role in hair loss and needs more research to understand its impact.

research Platelet-Rich Plasma in Dermatology: Boon or Bane?

119 citations , January 2014 in “Indian Journal of Dermatology, Venereology and Leprology”

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , August 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.