A Comparative Study of Therapeutic Response to Intralesional Injections of Platelet-Rich Plasma Versus Triamcinolone Acetonide in Alopecia Areata

January 2020 in “ Indian Dermatology Online Journal ”

Anumod Balakrishnan, Bifi Joy, Anoop Thyvalappil, Pretty Mathew, Ajayakumar Sreenivasan, Rajiv Sridharan

platelet-rich plasma triamcinolone acetonide alopecia areata intralesional injections steroids PRP

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Triamcinolone Acetonide →

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary In this study, PRP injections showed comparable effectiveness to triamcinolone for alopecia areata, with a significant decrease in SALT score at one interval, and 12.5% of patients in the PRP group experienced excellent hair regrowth compared to none in the triamcinolone group.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study compared the effectiveness of intralesional platelet-rich plasma (PRP) versus triamcinolone acetonide in treating alopecia areata over 12 weeks with 40 patients, 16 completing the study in each group. Both treatments showed similar outcomes, but PRP demonstrated a statistically significant earlier response at 8 weeks and had a higher percentage of patients reporting excellent and good responses. Side effects were minimal, with severe pain reported by 3 patients in the PRP group. PRP was found to be a safe and effective alternative to steroids, though the study's small sample size and short follow-up duration necessitated further research.

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research Platelet-Rich Plasma Stimulates Angiogenesis in Mice Which May Promote Hair Growth

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In this study, platelet-rich plasma injections in mice promoted hair growth and angiogenesis compared to control, as evidenced by longer hair lengths and increased vessel formation.

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This study found that platelet-rich plasma was more effective for treating alopecia areata than topical 5% minoxidil, leading to earlier hair regrowth and reduction in hair abnormalities.

research Role of Platelet-Rich Plasma in Chronic Alopecia Areata: Our Centre Experience

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This study found that platelet-rich plasma may have a role in treating chronic alopecia areata, but more long-term follow-up studies are needed to confirm its effectiveness and success rate.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

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This study reported that AA-PRP injections significantly increased hair count and density in individuals with pattern hair loss compared to baseline, demonstrating their potential for enhancing hair growth.

research Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool

115 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

In this study, PRP injections increased hair count and reduced hair loss in patients with androgenic alopecia not responding to minoxidil and finasteride, with high patient satisfaction reported.

A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , April 2013 in “British Journal of Dermatology”

In this study, platelet-rich plasma significantly increased hair regrowth and reduced symptoms of alopecia areata compared to triamcinolone acetonide or placebo, with no observed side effects.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.

research Pitx2, A β-Catenin-Regulated Transcription Factor, Regulates The Differentiation Of Outer Root Sheath Cells Cultured In Vitro

51 citations , February 2009 in “Journal of dermatological science”

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research Intralesional Treatment of Alopecia Areata with Triamcinolone Acetonide by Jet Injector

100 citations , July 2006 in “British Journal of Dermatology”

This study found that intralesional triamcinolone acetonide injections using a needleless injector led to rapid hair regrowth in patients with limited alopecia areata, while lasting growth was rare in alopecia totalis.

research Management of Hair Loss

74 citations , April 2005 in “Dermatologic Clinics”

This article reviews treatment options for male-pattern and female-pattern hair loss, telogen effluvium, and alopecia areata, but provides no new clinical results; algorithmic management approaches are included.

research A Comparison of Intralesional Triamcinolone Hexacetonide and Triamcinolone Acetonide in Alopecia Areata

75 citations , September 1971 in “British Journal of Dermatology”

This study found that both intralesional triamcinolone acetonide and triamcinolone hexacetonide promote continuous hair growth in alopecia areata, with effects lasting at least 9 months after a single injection.