TLDR Combining triamcinolone acetonide and immunotherapy can help regrow hair in some alopecia totalis patients.
The study assessed the potential for hair regrowth in 10 patients with alopecia totalis (AT) who did not respond to topical immunotherapies. Patients received monthly injections of triamcinolone acetonide (TA), followed by immunotherapy using squaric acid dibutylester (SADBE) or diphenylcyclopropenone (DPCP) if vellus hair developed. The complete response rate to TA was 10%, while the partially good response rate was 60%. Good responders showed the anagen stage of hair follicle after TA injections, and the complete responder exhibited further hair regrowth with subsequent immunotherapy. The study suggested that even long-term AT patients could potentially recover their hair cycle with this combined treatment approach.
44 citations
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April 2017 in “International Journal of Dermatology” No treatment is completely effective for alopecia totalis and alopecia universalis.
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November 2016 in “Journal of The American Academy of Dermatology” Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.
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July 2013 in “DOAJ (DOAJ: Directory of Open Access Journals)” Minoxidil can effectively treat patchy hair loss by stimulating hair growth.
