Nanovesicles from Adipose Derived Stem Cells Delay Hair Follicle Degeneration and Stimulate Regeneration: A Novel Therapeutic Strategy for Androgenetic Alopecia

This study explores the use of nanovesicles derived from adipose stem cells (ADSC-NV) as a treatment for androgenetic alopecia. The nanovesicles, with an average diameter of 87.3 nm, were shown to significantly promote the proliferation and migration of dermal papilla cells (DPC) and slow hair follicle degeneration in vitro. In vivo experiments on mice demonstrated that intradermal injections of ADSC-NV enhanced hair regeneration, reversed hair follicle miniaturization, and accelerated the transition from the telogen to anagen phase, achieving effects comparable to minoxidil while also reducing sebum secretion. These findings suggest that ADSC-NV could be a promising therapeutic strategy for androgenetic alopecia.