Novel Recombinant R-Spondin1 Promotes Hair Regeneration by Targeting the Wnt/β-Catenin Signaling Pathway

    June 2023 in “ Acta Biochimica et Biophysica Sinica ”
    Yijun Chen, Zhu-jin Lu, Jiaxin Feng … Chun‐qi Gao
    Studysummary In this study, a subcutaneous injection of recombinant RSPO1 was found to activate hair follicle stem cells and enhance hair regeneration in mice by stimulating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciengine.com →
    Discuss this study in the Community →

    Research cited in this study 13

    1. Mesenchymal Stem Cells From Mouse Hair Follicles Reduce Hypertrophic Scarring in a Murine Wound Healing Model Stem cell reviews and reports · 2022
    2. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    3. Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Frontiers in Cell and Developmental Biology · 2020
    4. IL-36α Promoted Wound-Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation Frontiers in Cell and Developmental Biology · 2020
    5. Meta-Analysis on the Efficacy and Safety of Traditional Chinese Medicine as Adjuvant Therapy for Refractory Androgenetic Alopecia Evidence-based Complementary and Alternative Medicine · 2019
    6. Finasteride and Androgenic Alopecia: From Therapeutic Options to Medical Implications Journal of Dermatological Treatment · 2019
    7. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019
    8. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    9. Stimulation of Mouse Vibrissal Follicle Growth by Recombinant Human Fibroblast Growth Factor 20 Biotechnology Letters · 2018
    10. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    11. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    12. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    13. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011

    Related research 5

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle Experimental and Therapeutic Medicine · 2016
    3. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006