Novel Recombinant R-Spondin1 Promotes Hair Regeneration by Targeting the Wnt/β-Catenin Signaling Pathway

June 2023 in “ Acta Biochimica et Biophysica Sinica ”

Yijun Chen, Zhu-jin Lu, Jiaxin Feng, Zefeng Chen, Zejian Liu, Xiuqi Wang, Hui‐chao Yan, Chun‐qi Gao

recombinant R-spondin1 rRSPO1 Wnt/β-catenin signaling pathway hair regeneration hair follicle structure hair follicle stem cell proliferation telogen phase anagen phase

Studysummary In this study, a subcutaneous injection of recombinant RSPO1 was found to activate hair follicle stem cells and enhance hair regeneration in mice by stimulating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigates the effects of a novel recombinant protein, rRSPO1, on hair regeneration by targeting the Wnt/β-catenin signaling pathway in male C57BL/6 mice. With 16 mice divided into two groups, one receiving rRSPO1 injections, results showed that rRSPO1 significantly accelerated hair growth and improved hair follicle structure. The treatment increased the number, diameter, and length of hair follicles, indicating enhanced hair regrowth. rRSPO1 activates the Wnt/β-catenin signaling pathway, increasing the expression of proteins crucial for hair follicle stem cell proliferation and differentiation. The findings suggest rRSPO1 could be a promising candidate for hair regeneration therapy by facilitating the transition of hair follicles from the telogen to anagen phase, promoting hair growth.

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