Autophagy Critically Controls Skin Inflammation and Apoptosis-Induced Stem Cell Activation

    August 2023 in “ Autophagy ”
    Lisette Van Hove, Annagiada Toniolo, Mohammad Ghiasloo, Kim Lecomte, Fleur Boone, Maarten Ciers, Kris Raaijmakers, Niels Vandamme, Jana Roels, Sophia Maschalidi, Kodi S. Ravichandran, Maria Kasper, Geert Loo, Esther Hoste
    Image of study
    TLDR Autophagy helps control skin inflammation and cancer responses and regulates hair growth by affecting stem cell activity.
    The study demonstrates that keratinocyte-specific ablation of the autophagy mediator Atg16l1 in mice leads to increased skin inflammation, heightened sensitivity to apoptosis, and enhanced tumor formation. These mice also show an earlier onset of hair follicle growth and expanded regenerative potential of hair follicle stem cells (HFSCs), including de novo hair follicle formation and improved wound healing. The findings suggest that autophagy in keratinocytes plays a crucial role in controlling skin inflammation and tumorigenesis while restraining HFSC activation by modulating apoptotic responses.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 11 results

      community Ruxolitinib - Start of a case study

      in Research/Science  10 upvotes 5 months ago
      The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

      community Topical rapamycin, metformin, a-kg grow hair

      in Research/Science  13 upvotes 4 years ago
      The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

      community Is there any new drug that looks promising ?

      in Research/Science  25 upvotes 8 months ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

      community How uninformed the general public is about hair loss

      in Chat  313 upvotes 9 months ago
      The conversation highlights the general public's lack of knowledge about hair loss, with various ineffective remedies suggested, such as not wearing hats or using hair fibers. The only effective treatments mentioned for male pattern baldness are medications like minoxidil and finasteride, and hair transplants.

    Similar Research

    5 / 714 results