Autophagy Critically Controls Skin Inflammation and Apoptosis-Induced Stem Cell Activation

    August 2023 in “ Autophagy ”
    Lisette Van Hove, Annagiada Toniolo, Mohammad Ghiasloo … Esther Hoste
    Studysummary In this study, researchers found that keratinocyte-specific deletion of the autophagy mediator Atg16l1 in mice heightened skin inflammation and cancer responses, altered hair follicle stem cell activity, and sensitized keratinocytes to cell death.
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    Research cited in this study 13

    1. Plasticity of Epithelial Cells During Skin Wound Healing Cold Spring Harbor Perspectives in Biology · 2022
    2. Wound-Induced Hair Neogenesis Model Journal of Investigative Dermatology · 2022
    3. Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State Developmental cell · 2022
    4. Building and Maintaining the Skin Cold Spring Harbor Perspectives in Biology · 2021
    5. Autophagy Protects Murine Preputial Glands Against Premature Aging and Controls Their Sebum Phospholipid and Pheromone Profile Autophagy · 2021
    6. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    7. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    8. Stretching the Limits: From Homeostasis to Stem Cell Plasticity in Wound Healing and Cancer Nature Reviews Genetics · 2018
    9. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015
    10. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    11. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    12. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    13. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006