TLDR Autophagy prevents early aging and maintains lipid and pheromone balance in mouse glands.
The study demonstrated that autophagy, particularly ATG7-dependent macroautophagy, was crucial for maintaining the health and function of murine preputial glands. Inactivation of autophagy led to premature aging, ductal ectasia, and altered lipid droplet morphology. Single-cell RNA sequencing revealed downregulation of genes involved in lipid metabolism and oxidative stress response in ATG7-deficient glands. Lipid analysis showed decreased levels of most phospholipid classes and an accumulation of diacylglycerides, along with a significant reduction in the pheromone palmityl acetate. These findings highlighted the essential role of autophagy in gland homeostasis, lipid metabolism, and pheromone production.
27 citations,
July 2018 in “Experimental dermatology” Autophagy is crucial for normal sebaceous gland function and sebum composition.
107 citations,
August 2012 in “Seminars in Cell & Developmental Biology” The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.
31 citations,
July 2012 in “Journal of Lipid Research” ACBP is crucial for healthy skin in mice.
127 citations,
December 2005 in “Experimental Dermatology” Stress can stop hair growth in mice, and treatments can reverse this effect.
194 citations,
March 2003 in “American Journal of Pathology” Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.
January 2022 in “Figshare” Autophagy helps mouse glands stay healthy, prevents early aging, and maintains their oil and scent production.
January 2021 in “Figshare” Autophagy helps delay aging in mouse glands, maintains fat balance, and controls scent production.
27 citations,
July 2018 in “Experimental dermatology” Autophagy is crucial for normal sebaceous gland function and sebum composition.
Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.
2 citations,
August 2023 in “Autophagy” Autophagy helps control skin inflammation and cancer responses and regulates hair growth by affecting stem cell activity.
