Plasticity of Epithelial Cells During Skin Wound Healing

November 2022 in “ Cold Spring Harbor Perspectives in Biology ”

Xiaoyan Sun, Simon Joost, Maria Kasper

epithelial cells stem cells interfollicular epidermis hair follicles reepithelialization wound healing skin barrier function

TLDR Epithelial cells adapt and work together to heal skin wounds effectively.

The document reviewed the plasticity of epithelial cells during skin wound healing, focusing on how stem cells from different niches in the skin, such as the interfollicular epidermis and hair follicles, contribute to reepithelialization after injury. It discussed the mechanisms by which these cells sense and respond to damage, regulate their identity, and retain memory of their origin. The review highlighted the adaptability of epithelial cells as a key factor in effective wound repair, emphasizing their ability to leave their niches and work collectively to restore the skin's barrier function.

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