Hair Follicle Stem Cell Progeny Heal Blisters While Pausing Skin Development

June 2021 in “ EMBO reports ”

Yoshihiko Fujimura, Mika Watanabe, Katsutoshi Ohno, Yasuaki Kobayashi, Shota Takashima, Hideki Nakamura, Hideyuki Kosumi, Yunan Wang, Yosuke Mai, Andrea Lauria, Valentina Proserpio, Hideyuki Ujiie, Hiroaki Iwata, Wataru Nishie, Masaharu Nagayama, Salvatore Oliviero, Giacomo Donati, Hiroshi Shimizu, Ken Natsuga

hair follicle stem cells HFSCs blisters skin development tissue morphogenesis hair follicle growth junctional zone stem cells dermis interfollicular epidermis epidermolysis bullosa pemphigoid diseases skin blisters skin healing blistering diseases

TLDR When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.

The study "Hair follicle stem cell progeny heal blisters while pausing skin development" found that hair follicle stem cells (HFSCs) are crucial in healing skin blisters. When skin is injured, it prioritizes healing over development, as shown by the healing of blisters suppressing tissue morphogenesis genes and delaying hair follicle growth. The progeny of hair follicle junctional zone stem cells are primarily responsible for repairing the blisters, while not promoting hair follicle development. The study also found that when most hair follicles are detached from the dermis, the interfollicular epidermis can compensate and repair defects. The research involved multiple biological replicates, with the exact number varying depending on the specific experiment. The findings could lead to tailored therapeutic interventions for blistering diseases such as epidermolysis bullosa and pemphigoid diseases.

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Research cited in this study

15 / 15 results

research Hair Follicle Stem Cell Progeny Heal Blisters While Pausing Skin Development

10 citations , June 2021 in “EMBO reports”

When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.

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87 citations , January 2016 in “Development”

Blocking β-catenin in skin cells improves hair growth during wound healing.

research Stem Cell Heterogeneity and Plasticity in Epithelia

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Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations , June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

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The document suggests that certain protein deficiencies and scalp blistering in Epidermolysis Bullosa may cause hair loss.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

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Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”

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