TLDR Collagen XVII is vital for skin structure, hair stem cell support, and skin cell regulation.
The document reviewed the role of type XVII collagen (COL17) in epidermal physiology, highlighting its critical function in skin structure, stem cell regulation, and its involvement in diseases like junctional epidermolysis bullosa and bullous pemphigoid. COL17 was essential in hair follicles, where its deficiency led to hair loss and greying due to stem cell exhaustion, suggesting its potential as a therapeutic target for skin aging and age-related alopecia. The study also examined COL17's interaction with various signaling pathways, such as TGF-β, Wnt, and STAT3, affecting cell proliferation and differentiation. Although increased COL17 expression was noted in some cancers, its role in skin cancer risk was unclear, indicating a need for further research to explore its differential expression and therapeutic potential for blistering diseases.
124 citations
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July 2017 in “eLife” Type XVII collagen helps control skin cell growth and could be a target for anti-aging treatments.
242 citations
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February 2016 in “Science” Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
24 citations
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June 2015 in “Journal of Investigative Dermatology” aPKCλ is crucial for keeping hair follicle stem cells inactive and maintaining normal hair growth.
32 citations
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December 2014 in “Cold Spring Harbor Perspectives in Medicine” Disruptions in epidermal polarity genes can lead to skin diseases.
27 citations
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July 2013 in “Journal of Investigative Dermatology” Revertant cell therapy shows promise for treating type XVII collagen deficiency, but better cell selection methods are needed.
260 citations
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December 2012 in “Cold Spring Harbor Perspectives in Biology” Wnt signaling is crucial for skin development and health, and its disruption can cause skin diseases.
283 citations
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February 2011 in “Cell stem cell” 297 citations
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January 2002 in “Development” Overexpression of ΔNLef1 in mouse skin leads to hair loss, cysts, and skin tumors.
January 1997 in “Han-guk hyeonmigyeong hakoeji/Applied microscopy” The hair follicle's connection to connective tissue is weaker than the skin's.
