Life Before and Beyond Blistering: The Role of Collagen XVII in Epidermal Physiology
March 2018
in “
Experimental Dermatology
”
Research cited in this study
6 / 6 resultsresearch Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis
Type XVII collagen helps control skin cell growth and could be a target for anti-aging treatments.
research Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis
Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
research Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence
aPKCλ is crucial for keeping hair follicle stem cells inactive and maintaining normal hair growth.
research Long-Term Survival of Type XVII Collagen Revertant Cells in an Animal Model of Revertant Cell Therapy
research Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells
research Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
Overexpression of ΔNLef1 in mouse skin leads to hair loss, cysts, and skin tumors.
Related Research
1 / 1 resultsresearch Ultrastructural Study on Connective Tissue-Epithelial Junctions in Anagen Hair Follicle of Human Fetus
This study examined the ultrastructural differences in connective tissue-epithelial junctions in anagen hair follicles of human fetal scalp skin. It found that the junctions around the dermal papilla and on the outside of the hair follicle differed significantly from those in the dermoepidermal junction of the skin. Notably, structures such as hemidesmosomes, tonofilaments, attachment plaques, sub-basal dense plates, and anchoring filaments, which were present in the skin, were absent in the dermal papilla. The basal lamina was smoother, and collagen fibers were orthogonally arranged on the outside of the hair follicle, unlike in the dermal papilla. These findings suggested that the mechanical connection between the hair follicle and connective tissue was weaker than in the skin, reflecting the dynamic nature of the anagen phase compared to the stable state of the epidermis.