Sox11 And Sox4 Drive The Reactivation Of An Embryonic Gene Program During Murine Wound Repair

    September 2019 in “ Nature Communications ”
    Qi Miao, Matthew C. Hill, Fengju Chen … Hoang Nguyen
    Studysummary In this study, researchers identified that upon tissue injury in a mouse model, epidermal cells at the wound edge convert to an embryonic-like state with SOX11 and SOX4 playing a central role in modulating epidermal development and cell migration genes.
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    Research cited in this study 5

    1. Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties Nature cell biology · 2017
    2. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    3. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    4. Tcf3 Promotes Cell Migration and Wound Repair Through Regulation of Lipocalin 2 Nature Communications · 2014
    5. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007