Tcf3 Promotes Cell Migration and Wound Repair Through Regulation of Lipocalin 2

In 2014, a study discovered that the transcription factor Tcf3 promotes cell migration and wound healing by regulating lipocalin 2 (Lcn2). The researchers found that Tcf3's induction in response to wound stimuli was dependent on another transcription factor, Stat3. Tcf3's pro-migration effects were non-cell autonomous and occurred independently of its interaction with the Wnt effector ß-catenin. The study identified Lcn2 as a critical downstream target of Tcf3 that promotes cell migration and wound healing. The application of Lcn2 accelerated wound closure significantly. These findings suggested potential therapeutic targets for the treatment of defective wound repair.