Beta-Caryophyllene Enhances Wound Healing Through Multiple Routes

The document from April 16, 2019, presents a study on the effects of beta-caryophyllene (BCP) on wound healing in mice. The study found that BCP-treated wounds showed improved re-epithelialization, with increased cell proliferation and migration, and up-regulation of genes for hair follicle bulge stem cells and Transient Receptor Potential channel genes. However, enhanced re-epithelialization was observed only in female mice. The study concluded that BCP, a compound in essential oils, can improve wound healing through multiple pathways, although the number of mice used in the study was not specified. Additionally, the study found that BCP did not alter self-grooming behaviors but did result in less movement in mice by post-surgery day 3, without signs of irritation or allergic responses. The sample sizes for the behavioral study ranged from 5 to 7 mice per group.