TLDR Beta-caryophyllene, found in essential oils, helps wounds heal better in multiple ways.
The document from April 16, 2019, presents a study on the effects of beta-caryophyllene (BCP) on wound healing in mice. The study found that BCP-treated wounds showed improved re-epithelialization, with increased cell proliferation and migration, and up-regulation of genes for hair follicle bulge stem cells and Transient Receptor Potential channel genes. However, enhanced re-epithelialization was observed only in female mice. The study concluded that BCP, a compound in essential oils, can improve wound healing through multiple pathways, although the number of mice used in the study was not specified. Additionally, the study found that BCP did not alter self-grooming behaviors but did result in less movement in mice by post-surgery day 3, without signs of irritation or allergic responses. The sample sizes for the behavioral study ranged from 5 to 7 mice per group.
Cited in this study
8 / 8 results
72 citations
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November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
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November 2017 in “Development” Fibroblast Growth Factors (FGFs) are important for tissue repair and regeneration, influencing cell behavior and other factors involved in healing, and are crucial in processes like wound healing, bone repair, and hair growth.
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July 2014 in “Cold Spring Harbor Perspectives in Medicine” The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.
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July 2013 in “Science” Mice without the Sept4/ARTS gene heal wounds better due to more stem cells that don't die easily.
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May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
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September 2005 in “Wound Repair and Regeneration” Hydrogen peroxide can cause scars by changing healing processes and increasing certain protein levels.
9 citations
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September 2002 in “The Journal of clinical investigation/The journal of clinical investigation” Blocking testosterone speeds up wound healing in males.
