Pharmacology of Natural Volatiles and Essential Oils in Food, Therapy, and Disease Prophylaxis

    October 2021 in “ Frontiers in Pharmacology
    Nicholas J. Sadgrove, Guillermo F. Padilla-González, Olga Leuner, Ingrid Melnikovová, Eloy Fernández Cusimamani
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    TLDR Natural volatiles and essential oils have health benefits and can enhance the effects of some medicines, but more research is needed to understand how they work and their possible side effects.
    The document "Pharmacology of Natural Volatiles and Essential Oils in Food, Therapy, and Disease Prophylaxis" discusses the therapeutic potential of natural volatiles and essential oils. These substances, found in various plants, possess antimicrobial, anti-inflammatory, and antioxidant properties, and can be used in food preservation, therapy, and disease prevention. They can penetrate the skin effectively and have potential therapeutic outcomes ranging from anti-inflammatory effects to insulin sensitisation, dermal rejuvenation, keratinocyte migration, upregulation of hair follicle bulb stem cells, and complementation of anti-cancer therapies. The document also discusses the pharmacokinetics of these substances, including their absorption, distribution, metabolism, and excretion. Essential oils and volatile organic compounds often act as potentiators in combination with pharmaceuticals, enhancing their effects. They can also promote wound healing and upregulate hair follicle stem cells, which has implications for hair health. The document concludes that while these substances have significant potential, more research is needed to fully understand their mechanisms of action and potential side effects.
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