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The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men

research The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men

33 citations, November 2008 in “European Journal of Pharmaceutical Sciences”

St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.

research Female Pattern Hair Loss, Sebum Excretion, and the End-Organ Response to Androgens

31 citations, October 2005 in “British Journal of Dermatology”

Hair loss in women not always linked to increased oil production; other factors may be involved.

Changes in Serum Free Testosterone, Sleep Patterns, and 5-Alpha-Reductase Type I Activity Influence Sebum Excretion in Female Subjects

research Changes in Serum Free Testosterone, Sleep Patterns, and 5-Alpha-Reductase Type I Activity Influence Sebum Excretion in Female Subjects

10 citations, August 2014 in “Skin research and technology”

Sleep, testosterone levels, and a specific enzyme activity affect skin oil production in women.

research Effect of the Gonadotrophin-Releasing Hormone Analogue, Goserelin, and Estradiol Replacement on Sebum Excretion Rates and Hair Size in Mildly Hirsute Women

4 citations, January 1991 in “Journal of dermatological treatment”

Goserelin and oestradiol treatment slightly improved hairiness but did not significantly change sebum production or hair characteristics in mildly hirsute women.

research Felinine Excretion in Domestic Cat Breeds: A Preliminary Investigation

2 citations, July 2013 in “Journal of Animal Physiology and Animal Nutrition”

Shorthaired and hairless cat breeds excrete more felinine than longhaired breeds.

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community How does finasteride leave your body?

in Chat 13 upvotes 9 months ago

Finasteride is metabolized in the liver and excreted through urine and feces. Users humorously discuss its excretion, with one joking about it being expelled through ejaculation.

community anti-androgens help with chronic seborric dermatitis ?! and hence diffuse thinning

in Finasteride/Dutasteride 6 upvotes 1 month ago

An 18-year-old experiencing hair loss and seborrheic dermatitis has tried finasteride, dutasteride, and various shampoos without success. They are considering anti-androgens like RU58841 and KX-826 for oil control and dandruff reduction.

community Increased Coffee intake resulted in massive shed

in Finasteride/Dutasteride 18 upvotes 2 months ago

Increased coffee intake might be linked to hair shedding, but the cause is unclear. The user is on finasteride and has increased water intake, possibly affecting electrolyte balance.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 9 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 62 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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