Effect of the Gonadotrophin-Releasing Hormone Analogue, Goserelin, and Estradiol Replacement on Sebum Excretion Rates and Hair Size in Mildly Hirsute Women

January 1991 in “ Journal of dermatological treatment ”

Marius Rademaker, N. B. Simpson, Johannes Gudmundsson, M Bonduelle, Richard Fleming, J. R. T. Coutts

gonadotrophin-releasing hormone analogue goserelin oestradiol replacement sebum excretion rates hair size hirsutism androgen-related skin conditions GnRH analogue Zoladex estrogen replacement oil production hair thickness excess hair growth androgen-related skin issues

TLDR Goserelin and oestradiol treatment slightly improved hairiness but did not significantly change sebum production or hair characteristics in mildly hirsute women.

The study investigated the effects of the gonadotrophin-releasing hormone analogue, goserelin, and oestradiol replacement on sebum excretion rates and hair size in mildly hirsute women. The research aimed to understand how these treatments influenced androgen-related skin and hair conditions. The findings indicated that goserelin significantly reduced sebum excretion rates, while oestradiol replacement helped maintain hair size. This suggested that manipulating hormone levels could effectively manage symptoms of mild hirsutism.

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Effect of the Gonadotrophin-Releasing Hormone Analogue, Goserelin, and Estradiol Replacement on Sebum Excretion Rates and Hair Size in Mildly Hirsute Women

Research cited in this study

research Lack of Effect of Spironolactone on Hair Shaft Diameter in Hirsute Females

research The Effect of Spironolactone on Genital Skin 5α-Reductase Activity

research Oral Spironolactone Therapy for Female Patients with Acne, Hirsutism, or Androgenic Alopecia

research Androgen Metabolism in Hirsute Patients Treated with Cyproterone Acetate

research Effect of Cyproterone Acetate on Hair Growth, Sebaceous Secretion, and Endocrine Parameters in a Hirsute Subject

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