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GlossaryGoserelin

reduces sex hormone production to treat hormone-sensitive cancers

Goserelin, also known by the brand name Zoladex, is a type of medication called a gonadotropin-releasing hormone (GnRH) agonist. It is used to treat hormone-sensitive cancers such as prostate cancer in men and breast cancer in premenopausal women, as well as certain benign gynecological conditions like endometriosis. Goserelin works by reducing the production of sex hormones (testosterone and estrogen), which can help slow the growth of hormone-dependent tumors.

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research An Open Randomized Comparative Study of an Oral Contraceptive Containing Ethinyl Estradiol and Cyproterone Acetate with and without the GnRH Analogue Goserelin in the Long-Term Treatment of Hirsutism

18 citations, January 1996 in “Gynecologic and obstetric investigation”

The oral contraceptive alone is the preferred treatment for hirsutism, as adding the GnRH analog showed no significant benefit.

research Effect of the Gonadotrophin-Releasing Hormone Analogue, Goserelin, and Estradiol Replacement on Sebum Excretion Rates and Hair Size in Mildly Hirsute Women

4 citations, January 1991 in “Journal of dermatological treatment”

Goserelin and oestradiol treatment slightly improved hairiness but did not significantly change sebum production or hair characteristics in mildly hirsute women.

research Enzalutamide, Finasteride, Goserelin, Zoledronic Acid

July 2024 in “Reactions Weekly”

research Frontal Fibrosing Alopecia After Antiandrogen Hormonal Therapy in a Male Patient

9 citations, January 2018 in “Journal of the European Academy of Dermatology and Venereology”

A male patient developed frontal fibrosing alopecia after antiandrogen therapy for prostate cancer.

research Slow Progress in Prostate Cancer

February 2007 in “BJUI”

Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.

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