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GlossaryGoserelin (Zoladex)

reduces sex hormone production to treat hormone-sensitive cancers

Goserelin, also known by the brand name Zoladex, is a type of medication called a gonadotropin-releasing hormone (GnRH) agonist. It is used to treat hormone-sensitive cancers such as prostate cancer in men and breast cancer in premenopausal women, as well as certain benign gynecological conditions like endometriosis. Goserelin works by reducing the production of sex hormones (testosterone and estrogen), which can help slow the growth of hormone-dependent tumors.

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research Effect of the Gonadotrophin-Releasing Hormone Analogue, Goserelin, and Estradiol Replacement on Sebum Excretion Rates and Hair Size in Mildly Hirsute Women

4 citations , January 1991 in “Journal of dermatological treatment”

Goserelin and oestradiol treatment slightly improved hairiness but did not significantly change sebum production or hair characteristics in mildly hirsute women.

research Recurrent Priapism in a Sickle Cell Disease Patient Treated with Gonadotropin-Releasing Hormone Agonists: A Case Report

February 2026 in “The Journal of Sexual Medicine”

GnRH agonists can help manage recurrent priapism in sickle cell patients, but long-term safety is unclear.

research SUN-106 Nonsurgical Management of Hyperandrogenism in a Postmenopausal Woman

October 2025 in “Journal of the Endocrine Society”

Goserelin injections can effectively manage hyperandrogenism symptoms in postmenopausal women who can't have surgery.

research Slow Progress in Prostate Cancer

February 2007 in “BJUI”

Finasteride reduces prostate cancer risk but may increase high-grade tumors; new drugs and better diagnosis are in development, but funding and industry commitment are challenges.

research Triple Hormonal Blockade (ADT3): A Patient’s Perspective

January 2019 in “Oncogen”

Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.

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