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GlossaryDeoxycorticosterone

steroid hormone regulating salt and water balance in kidneys

Deoxycorticosterone (DOC) is a steroid hormone produced by the adrenal glands. It plays a role in regulating salt and water balance in the body by acting on the kidneys to promote sodium retention and potassium excretion. This hormone is a precursor in the biosynthesis of aldosterone, another key hormone involved in electrolyte and fluid balance.

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research The Acute Anticonvulsant Effects of Deoxycorticosterone in Developing Rats: Role of Metabolites and Mineralocorticoid-Receptor Responses

13 citations , November 2005 in “Epilepsia”

Deoxycorticosterone and its metabolites help prevent seizures by interacting with specific receptors.

research Deoxycorticosterone’s Anticonvulsant Effects in Infant Rats Are Blocked by Finasteride, but Not by Indomethacin

7 citations , April 2006 in “Experimental Neurology”

Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

research Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility

269 citations , May 2002 in “Journal of Neuroscience”

Stress increases neurosteroids that help prevent seizures.

research Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis

26 citations , July 2012 in “Epilepsy & Behavior”

Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.

research Relating Neurosteroid Modulation of Inhibitory Neurotransmission to Behavior

18 citations , September 2021 in “Journal of Neuroendocrinology”

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

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community risks with finasteride and dutasteride

in Research/Science 140 upvotes 4 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 72 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 189 upvotes 3 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 149 upvotes 4 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.