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GlossaryDeoxycorticosterone

steroid hormone regulating salt and water balance in kidneys

Deoxycorticosterone (DOC) is a steroid hormone produced by the adrenal glands. It plays a role in regulating salt and water balance in the body by acting on the kidneys to promote sodium retention and potassium excretion. This hormone is a precursor in the biosynthesis of aldosterone, another key hormone involved in electrolyte and fluid balance.

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research Deoxycorticosterone’s Anticonvulsant Effects in Infant Rats Are Blocked by Finasteride, but Not by Indomethacin

7 citations , August 2006 in “Experimental Neurology”

Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

research Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis

26 citations , September 2012 in “Epilepsy & Behavior”

Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.

research Relating Neurosteroid Modulation of Inhibitory Neurotransmission to Behavior

18 citations , September 2021 in “Journal of Neuroendocrinology”

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

research The Role of the Adrenal Glands in Regulating Onset of Winter Fur Growth in Mink (Mustela Vison)

16 citations , July 1992 in “The journal of experimental zoology/Journal of experimental zoology”

Adrenal glands delay the start of winter fur growth in mink.

research Bilateral Adrenalectomy Induces Early Onset of Summer Fur Growth in Mink (Mustela Vison)

5 citations , June 1995 in “Comparative biochemistry and physiology. Part C. Comparative pharmacology and toxicology/Comparative biochemistry and physiology. C. Comparative pharmacology and toxicology”

Removing mink's adrenal glands causes their summer fur to grow earlier.

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community risks with finasteride and dutasteride

in Research/Science 143 upvotes 4 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 74 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 192 upvotes 3 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 148 upvotes 4 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.