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GlossaryTetrahydrodeoxycorticosterone

neurosteroid modulating GABA_A receptor activity in the brain

Tetrahydrodeoxycorticosterone (THDOC) is a neurosteroid derived from the hormone deoxycorticosterone. It is known for its role in modulating the activity of the GABA_A receptor in the brain, which can influence mood, stress response, and seizure susceptibility. This compound is significant in both neuroscience and endocrinology for its potential effects on mental health and neurological conditions.

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research Deoxycorticosterone’s Anticonvulsant Effects in Infant Rats Are Blocked by Finasteride, but Not by Indomethacin

7 citations, August 2006 in “Experimental Neurology”

Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

research Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders

82 citations, August 2006 in “Pharmacology, Biochemistry and Behavior”

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

research Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia

33 citations, April 2015 in “Current Opinion in Endocrinology, Diabetes and Obesity”

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

research Finasteride-Induced Depression: New Insights Into Possible Pathomechanisms

22 citations, December 2010 in “Journal of Cosmetic Dermatology”

Finasteride may increase depression by reducing brain cell growth.

Early Postnatal Neuroactive Steroid Manipulation Differentially Affects Recognition Memory and Passive Avoidance Performance in Male Rats

research Early Postnatal Neuroactive Steroid Manipulation Differentially Affects Recognition Memory and Passive Avoidance Performance in Male Rats

2 citations, July 2020 in “Behavioural Brain Research”

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

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community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 149 upvotes 3 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.