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Glossary Tetrahydrodeoxycorticosterone

neurosteroid modulating GABA_A receptor activity in the brain

Tetrahydrodeoxycorticosterone (THDOC) is a neurosteroid derived from the hormone deoxycorticosterone. It is known for its role in modulating the activity of the GABA_A receptor in the brain, which can influence mood, stress response, and seizure susceptibility. This compound is significant in both neuroscience and endocrinology for its potential effects on mental health and neurological conditions.

Research

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research Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA_AReceptors

248 citations , December 2011 in “Journal of Neuroscience”

This study demonstrated that stress-derived neurosteroid THDOC shifts from inhibiting to activating the HPA axis under stress, presenting potential therapeutic targets for stress-related disorders.

research The Acute Anticonvulsant Effects of Deoxycorticosterone in Developing Rats: Role of Metabolites and Mineralocorticoid‐receptor Responses

13 citations , November 2005 in “Epilepsia”

This study suggests that the anticonvulsant effects of deoxycorticosterone in young rats may be mediated by its metabolites and interactions with multiple receptors, including mineralocorticoid and progesterone receptors.

research Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes

44 citations , February 2009 in “Pain”

This study found that progesterone can inhibit spinal reflex potentiation in ovariectomized rats through GABA(A) receptor activity, mediated by neurosteroid metabolism rather than direct progesterone receptor action.

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