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GlossaryTetrahydrodeoxycorticosterone

neurosteroid modulating GABA_A receptor activity in the brain

Tetrahydrodeoxycorticosterone (THDOC) is a neurosteroid derived from the hormone deoxycorticosterone. It is known for its role in modulating the activity of the GABA_A receptor in the brain, which can influence mood, stress response, and seizure susceptibility. This compound is significant in both neuroscience and endocrinology for its potential effects on mental health and neurological conditions.

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research Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA-A Receptors

248 citations , December 2011 in “Journal of Neuroscience”

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

research Neuroactive Steroids Inhibit Spinal Reflex Potentiation by Selectively Enhancing Specific Spinal GABAA Receptor Subtypes

44 citations , February 2009 in “Pain”

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

research The Acute Anticonvulsant Effects of Deoxycorticosterone in Developing Rats: Role of Metabolites and Mineralocorticoid-Receptor Responses

13 citations , November 2005 in “Epilepsia”

Deoxycorticosterone and its metabolites help prevent seizures by interacting with specific receptors.

research Deoxycorticosterone’s Anticonvulsant Effects in Infant Rats Are Blocked by Finasteride, but Not by Indomethacin

7 citations , April 2006 in “Experimental Neurology”

Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

research Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders

82 citations , August 2006 in “Pharmacology, Biochemistry and Behavior”

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

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community risks with finasteride and dutasteride

in Research/Science 144 upvotes 4 months ago

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community 18M 8 months progress 40mg daily dut stack

in Progress Pictures 112 upvotes 6 months ago

An 18-year-old is using a high-dose hair loss treatment with 40mg daily dutasteride, finasteride, minoxidil, tretinoin, and topical bicalutamide. Despite health risk concerns, especially liver issues, they report hair regrowth progress and intend to continue the regimen.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 150 upvotes 4 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.