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    Glossary Tetrahydrodeoxycorticosterone

    neurosteroid modulating GABA_A receptor activity in the brain

    Tetrahydrodeoxycorticosterone (THDOC) is a neurosteroid derived from the hormone deoxycorticosterone. It is known for its role in modulating the activity of the GABA_A receptor in the brain, which can influence mood, stress response, and seizure susceptibility. This compound is significant in both neuroscience and endocrinology for its potential effects on mental health and neurological conditions.

    Research 3 of 40

    1. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations
    2. The Acute Anticonvulsant Effects of Deoxycorticosterone in Developing Rats: Role of Metabolites and Mineralocorticoid‐receptor Responses Epilepsia · 2005 · 13 citations
    3. Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes Pain · 2009 · 44 citations
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