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    Glossary Tetrahydrodeoxycorticosterone

    neurosteroid modulating GABA_A receptor activity in the brain

    Tetrahydrodeoxycorticosterone (THDOC) is a neurosteroid derived from the hormone deoxycorticosterone. It is known for its role in modulating the activity of the GABA_A receptor in the brain, which can influence mood, stress response, and seizure susceptibility. This compound is significant in both neuroscience and endocrinology for its potential effects on mental health and neurological conditions.

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    1. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations
    2. The Acute Anticonvulsant Effects of Deoxycorticosterone in Developing Rats: Role of Metabolites and Mineralocorticoid‐receptor Responses Epilepsia · 2005 · 13 citations
    3. Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes Pain · 2009 · 44 citations
    4. Neurosteroid Synthesis-Mediated Regulation of GABA<sub>A</sub>Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007 · 238 citations
    5. Neurosteroids, neuroactive steroids, and symptoms of affective disorders Pharmacology, Biochemistry and Behavior · 2006 · 82 citations
    6. Finasteride-induced depression: new insights into possible pathomechanisms Journal of Cosmetic Dermatology · 2010 · 22 citations
    7. Neuroactive Steroids and Ethanol Exposure: Relevance to Ethanol Sensitivity and Alcohol Use Disorders Risk Elsevier eBooks · 2019 · 1 citations
    8. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA<sub>A</sub>Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002 · 269 citations
    9. Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010 · 223 citations
    10. Changes in Expression and Function of Extrasynaptic GABA<sub>A</sub>Receptors in the Rat Hippocampus during Pregnancy and after Delivery Journal of Neuroscience · 2009 · 86 citations
    11. Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome The Journal of Clinical Endocrinology & Metabolism · 2016 · 40 citations
    12. Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites Frontiers in Neuroendocrinology · 2020 · 18 citations
    13. Isoallopregnanolone reduces tic‐like behaviours in the D1 CT ‐7 mouse model of Tourette syndrome Journal of Neuroendocrinology · 2019 · 15 citations
    14. Effect of the allopregnanolone and allotetrahydrodeoxycorticosteron on spike-wave discharges in the EEG of absence epilepsy rat models General Physiology and Biophysics · 2018 · 4 citations
    15. The Impact of the 5α-Reductase Inhibitors (5α-RIs) on Male Sexual Function and Psychological Well-Being Current Sexual Health Reports · 2015 · 1 citations
    16. Neuropsychological Assessment in Elderly Men with Benign Prostatic Hyperplasia Treated with Dutasteride Clinical Drug Investigation · 2018 · 20 citations
    17. Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model Scientific reports · 2019 · 6 citations
    18. GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride Neuropsychopharmacology · 2005 · 134 citations
    19. Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research Journal of Neuroendocrinology · 2015 · 123 citations
    20. Novel modulatory effects of neurosteroids and benzodiazepines on excitatory and inhibitory neurons excitability: a multi-electrode array recording study Frontiers in Neural Circuits · 2012 · 19 citations
    21. Enhanced Sensitivity to Ethanol-Induced Inhibition of LTP in CA1 Pyramidal Neurons of Socially Isolated C57BL/6J Mice: Role of Neurosteroids Frontiers in Endocrinology · 2011 · 19 citations
    22. Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus Journal of Neurophysiology · 2006 · 19 citations
    23. Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction Behavioural Brain Research · 2014 · 15 citations
    24. Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice Neuroscience · 2009 · 12 citations
    25. Early post-natal neuroactive steroid manipulation modulates ondansetron effects on initial periods of alcohol consumption in rats Physiology & behavior · 2018 · 2 citations
    26. Early postnatal inhibition of neurosteroid synthesis changes the later-life adverse outcome of neonatal asphyxia in rats Neuropharmacology · 2025
    27. Neurosteroids as Endogenous Regulators of Seizure Susceptibility 2002
    28. Antiepileptogenic effects of trilostane in the kainic acid model of temporal lobe epilepsy Epilepsia · 2023
    29. Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation Psychoneuroendocrinology · 2011 · 53 citations
    30. Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health International Journal of Molecular Sciences · 2024 · 45 citations