Deoxycorticosterone’s Anticonvulsant Effects in Infant Rats Are Blocked by Finasteride, but Not by Indomethacin

August 2006 in “ Experimental Neurology ”

Claudia Perez-Cruz, Sergei S. Likhodii, W. McIntyre Burnham

TLDR Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

The study investigated the anticonvulsant effects of deoxycorticosterone (DOC) and its metabolites, DHDOC and THDOC, in infant rats. DHDOC had the most pronounced anticonvulsant effects, with a better therapeutic index (TI) than DOC or THDOC. The study also found that finasteride blocked DOC's anticonvulsant effects, while indomethacin did not. DHDOC's anticonvulsant effects were not diminished by indomethacin, suggesting that its effects do not result from conversion into THDOC. The study suggests that DHDOC might be developed into an anticonvulsant drug for clinical use in children. Further research is needed to explore DHDOC's mechanism of action.

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3 / 3 results

Deoxycorticosterone’s Anticonvulsant Effects in Infant Rats Are Blocked by Finasteride, but Not by Indomethacin

Cited in this study

research Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition

research Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats

research Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor

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