TLDR Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.
The study investigated the anticonvulsant effects of deoxycorticosterone (DOC) and its metabolites, DHDOC and THDOC, in infant rats. DHDOC had the most pronounced anticonvulsant effects, with a better therapeutic index (TI) than DOC or THDOC. The study also found that finasteride blocked DOC's anticonvulsant effects, while indomethacin did not. DHDOC's anticonvulsant effects were not diminished by indomethacin, suggesting that its effects do not result from conversion into THDOC. The study suggests that DHDOC might be developed into an anticonvulsant drug for clinical use in children. Further research is needed to explore DHDOC's mechanism of action.
13 citations
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November 2005 in “Epilepsia” Deoxycorticosterone and its metabolites help prevent seizures by interacting with specific receptors.
269 citations
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May 2002 in “Journal of Neuroscience” Stress increases neurosteroids that help prevent seizures.
98 citations
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April 1997 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively blocks rat enzymes, but with varying methods and strength.
26 citations
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November 1993 in “Progress in Neuro-psychopharmacology & Biological Psychiatry” Treatment during development affects hormone balance and sexual behavior in male rats.
70 citations
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June 1993 in “Biochemistry” Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
7 citations
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April 2006 in “Experimental Neurology” Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.
48 citations
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February 1999 in “PubMed” Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.
30 citations
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August 1992 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride doesn't affect hormone levels in normal men.
