269 citations
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May 2002 in “Journal of Neuroscience” This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.
7 citations
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April 2006 in “Experimental Neurology” Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.
1 citations
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August 2016 This study investigated the cytotoxic effects of DHA derivatives on cancer cell lines and found that didocosahexaenoin was the most potent, inducing apoptosis and producing reactive oxygen species in PC3 prostate carcinoma cells.
September 2002 in “Epiliepsy currents/Epilepsy currents” This study found that deoxycorticosterone-derived neurosteroids modulate GABA A receptor function and may influence stress-induced changes in seizure susceptibility by elevating seizure thresholds in animal models.