Protein S-Palmitoylation as a Potential Therapeutic Target for Dermatoses

    December 2025 in “ Biomolecules ”
    Y. Feng, Jianxin Wu, Hui Tang … Xia Lei
    Studysummary This study reviews the emerging role of protein S-palmitoylation in dermatology, highlighting its impact on skin functions like inflammation and barrier maintenance, and evaluating its potential as a therapeutic target for skin disorders such as alopecia and psoriasis.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 4

    1. Role of S-Palmitoylation by ZDHHC13 in Mitochondrial Function and Metabolism in Liver Scientific reports · 2017
    2. Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2015
    3. Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2015
    4. Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase PLoS Genetics · 2010