Protein S-Palmitoylation as a Potential Therapeutic Target for Dermatoses

Protein S-palmitoylation, a reversible post-translational modification, is crucial in dermatology, influencing protein localization, stability, and interactions, and is implicated in conditions like alopecia and psoriasis. The review emphasizes the potential of targeting S-palmitoylation for therapeutic purposes, highlighting zDHHC enzymes' roles in skin health and disease. zDHHC13 is linked to hair growth and skin barrier integrity, while zDHHC5 affects inflammatory responses. The study suggests that targeting these enzymes could offer new treatments for skin disorders, although further research is needed to fully understand the mechanisms and develop specific inhibitors.