The Crosstalk Between PTEN-Induced Kinase 1-Mediated Mitophagy and the Inflammasome in the Pathogenesis of Alopecia Areata

    June 2023 in “ Experimental Dermatology ”
    Jung‐Min Shin, Kyung Min Kim, Mi Soo Choi … Young Lee
    Studysummary In this study, researchers found that inducing mitophagy can alleviate NLRP3 inflammasome activation in outer root sheath cells under conditions of mitochondrial stress, suggesting that targeting mitophagy and inflammasome interactions may offer new therapeutic approaches for alopecia areata.
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    Research cited in this study 5

    1. Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches Antioxidants · 2023
    2. Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy Experimental Dermatology · 2019
    3. Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles Scientific reports · 2017
    4. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    5. Pitx2, A β-Catenin-Regulated Transcription Factor, Regulates The Differentiation Of Outer Root Sheath Cells Cultured In Vitro Journal of dermatological science · 2009